Now showing items 21-40 of 58

    • Genetic variation associated with chromosomal aberration frequency: A genome‐wide association study 

      Niazi, Yasmeen; Thomsen, Hauke; Smolkova, Bozena; Vodickova, Ludmila; Vodenkova, Sona; Kroupa, Michal; Vymetalkova, Veronika; Kazimirova, Alena; Barancokova, Magdalena; Volkovova, Katarina; Staruchova, Marta; Hoffmann, Per; Nöthen, Markus M.; Dusinska, Maria; Musak, Ludovit; Vodicka, Pavel; Hemminki, Kari; Försti, Asta (Journal article; Peer reviewed, 2018)
    • Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment - A Review 

      Kohl, Yvonne; Rundén-Pran, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora Marte; Dusinska, Maria (Peer reviewed; Journal article, 2020)
      Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal ...
    • Global and gene specific DNA methylation in breast cancer cells was not affected during epithelial-to-mesenchymal transition in vitro 

      Smolkova, B.; Miklikova, S.; Kajabova, V. H.; Babelova, A.; El Yamani, Naouale; Zduriencikova, M.; Fridrichova, I.; Zmetakova, I.; Krivulcik, T.; Kalinkova, L.; Matuskova, M.; Kucerova, M.; Dusinska, Maria (Journal article; Peer reviewed, 2016)
    • The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders 

      Milić, Mirta; Ceppi, Marcello; Bruzzone, Marco; Azqueta, Amaya; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine; Møller, Peter; Teixeira, João Paulo; Alija, Avdulla; Anderson, Diana; Andrade, Vanessa; Andreoli, Cristina; Asllani, Fisnik; Eyluel Bangkoglu, Ezgi; Barancokova, Magdalena; Basaran, Nursen; Boutet-Robinet, Elisa; Buschini, Annamaria; Cavallo, Delia; Costa Pererira, Cristina; Costa, Carla; Costa, Solange; Da Silva, Juliana; Del Bo’, Cristian; Dimitrijevic Sreckovic, Vesna; Djelic, Ninoslav; Dobrzynska, Malgorzata; Duracková, Zdenka; Dvorakova, Monika; Gajski, Goran; Galati, Serena; García Lima, Omar; Giovannelli, Lisa; Goroshinskaya, Irina A.; Grindel, Annemarie; Gützkow, Kristine Bjerve; Hernández, Alba; Hernandez, Carlos; Holven, Kirsten Bjørklund; Ibero-Baraibar, Idoia; Ottestad, Inger Olaug; Kadioglu, Ela; Kazimirova, Alena; Kuznetsova, Elena; Ladeira, Carina; Laffon, Blanca; Lamonaca, Palma; Lebailly, Pierre; Louro, Henriqueta; Cardoso, Tania Mandina; Marcon, Francesca; Marcos, Ricard; Moretti, Massimo; Moretti, Silvia; Najafzadeh, Mojgan; Nemeth, Zsuzsanna; Neri, Monica; Novotna, Bozena; Orlow, Irene; Paduchova, Zuzana; Pastor, Susana; Perdry, Hervé; Spremo-Potparević, Biljana; Ramadhani, Dwi; Riso, Patrizia; Rohr, Paula; Rojas, Emilio; Rossner, Pavel; Safar, Anna; Sardas, Semra; Silva, Maria João; Sirota, Nikolay; Smolkova, Bozena; Staruchova, Marta; Stetina, Rudolf; Stopper, Helga; Surikova, Ekaterina I.; Ulven, Stine Marie; Ursini, Cinzia Lucia; Valdiglesias, Vanessa; Valverde, Mahara; Vodička, Pavel; Volkovova, Katarina; Wagner, Karl-Heinz; Zivkovic, Lada; Dusinska, Maria; Collins, Andrew Richard; Bonassi, Stefano (Peer reviewed; Journal article, 2021)
      The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those ...
    • Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model 

      Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2020)
      (1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures ...
    • High throughput toxicity screening and intracellular detection of nanomaterials 

      Collins, Andrew Richard; Balasubramanyam, Annangi; Rubio, Laura; Marcos, Ricard; Dorn, Marco; Merker, Carolin; Estrela-Lopis, Irina; Cimpan, Mihaela Roxana; Ibrahim, Mohamed; Cimpan, Emil; Ostermann, Melanie; Sauter, Alexander; El Yamani, Naouale; Shaposhnikov, Sergey; Chevillard, Sylvie; Paget, Vincent; Grall, Romain; Delic, Jozo; Goñi- de-Cerio, Felipe; Suarez-Merino, Blanca; Fessard, Valérie; Hogeveen, Kevin N; Fjellsbø, Lise Marie; Rundén-Pran, Elise; Brzicova, Tana; Topinka, Jan; João Silva, Maria; Leite, PE; Ribeiro, AR; Granjeiro, JM; Grafström, Roland; Prina-Mello, Adriele; Dusinska, Maria (Journal article; Peer reviewed, 2017)
    • Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing? 

      Dusinska, Maria; Tulinska, Jana; El Yamani, Naouale; Kuricova, Miroslava; Liskova, Aurelia; Rollerova, Eva; Rundén-Pran, Elise; Smolkova, Bozena (Journal article; Peer reviewed, 2017)
    • Impact of nanosilver on various DNA lesions and HPRT gene mutations – effects of charge and surface coating 

      Huk, Anna; Izak-Nau, Emilia; El Yamani, Naouale; Uggerud, Hilde Thelle; Vadset, Marit; Zasonska, Beata; Duschl, Albert; Dusinska, Maria (Journal article; Peer reviewed, 2015)
    • Impact of storage conditions and storage time on silver nanoparticles' physicochemical properties and implications for their biological effects 

      Izak-Nau, Emilia; Huk, Anna; Reidy, Bogumiła; Uggerud, Hilde Thelle; Vadset, Marit; Eiden, Stefanie; Voetz, Matthias; Himly, Martin; Duschl, Albert; Dusinska, Maria; Lynch, Iseult (Journal article; Peer reviewed, 2015)
    • Improving Quality in Nanoparticle-Induced Cytotoxicity Testing by a Tiered Inter-Laboratory Comparison Study 

      Nelissen, Inge; Haase, Andrea; Anguissola, Sergio; Rocks, Louise; Jacobs, An; Willems, Hanny; Riebeling, Christian; Luch, Andreas; Piret, Jean-Pascal; Toussaint, Olivier; Trouiller, Benedicte; Lacroix, Ghislaine; Gutleb, Arno C.; Contal, Servane; Diabaté, Silvia; Weiss, Carsten; Lozano-Fernandez, Tamara; Gonzalez-Fernandez, Africa; Dusinska, Maria; Huk, Anna; Stone, Vicki; Kanase, Nilesh; Nocun, Marek; Stepnik, Maciej; Meschini, Stefania; Ammendolia, Maria Grazia; Lewinski, Nastassja; Riediker, Michael; Venturini, Marco; Benetti, Frederico; Topinka, Jan; Brzicova, Tana; Milani, Silvia; Rädler, Joachim; Salvati, Anna; Dawson, Kenneth A. (Peer reviewed; Journal article, 2020)
      The quality and relevance of nanosafety studies constitute major challenges to ensure their key role as a supporting tool in sustainable innovation, and subsequent competitive economic advantage. However, the number of ...
    • In vitro evaluation of the genotoxicity of poly(anhydride) nanoparticles designed for oral drug delivery 

      Iglesias, T.; Dusinska, Maria; El Yamani, Naouale; Irache, J. M.; Azqueta, A.; de Cerain, A. López (Journal article; Peer reviewed, 2017)
    • In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment 

      El Yamani, Naouale; Collins, Andrew Richard; Rundén-Pran, Elise; Fjellsbø, Lise Marie; Shaposhnikov, Sergey; Zienolddiny, Shanbeh; Dusinska, Maria (Journal article; Peer reviewed, 2016)
    • Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation 

      Mech, A.; Rasmussen, K.; Jantunen, P.; Aicher, L.; Alessandrelli, M.; Bernauer, U.; Bleeker, E. A. J.; Bouillard, J.; Di Prospero Fanghella, P.; Draisci, R.; Dusinska, Maria; Encheva, G.; Flament, G.; Haase, A.; Handzhiyski, Y.; Herzberg, F.; Huwyler, J.; Jacobsen, N.R.; Jeliazkov, V.; Jeliazkova, N.; Nymark, P.; Grafström, R.; Oomen, A. G.; Polci, M. L.; Riebeling, C.; Sandström, J.; Shivachev, B.; Stateva, S.; Tanasescu, S.; Tsekovska, R.; Wallin, Håkan; Wilks, M. F.; Zellmer, S.; Apostolova, M. D. (Journal article; Peer reviewed, 2018)
      This paper presents a comprehensive review of European Union (EU) legislation addressing the safety of chemical substances, and possibilities within each piece of legislation for applying grouping and read-across approaches ...
    • INTARESE. Revised integrated monitoring. 

      Liu, Hai-Ying; Bartonova, Alena; Dusinska, Maria (NILU OR;28/2010, Research report, 2010)
      The aim of this report is to summarize the results from (i) review of existing and planned environment and health monitoring programs (section 2.1); (ii) review of frameworks which are currently used in the integrated ...
    • Is the toxic potential of nanosilver dependent on its size? 

      Huk, Anna; Izak-Nau, Emilia; Reidy, Bogumila; Boyles, Matthew; Duschl, Albert; Lynch, Iseult; Dusinska, Maria (Journal article; Peer reviewed, 2014)
    • Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening 

      Kohl, Yvonne; Biehl, Margit; Spring, Sarah; Hesler, Michelle; Ogourtsov, Vladimir; Todorovic, Miomir; Owen, Joshua; Elje, Elisabeth; Kopecka, Kristina; Moriones, Oscar Hernando; Bastus, Neus G.; Simon, Peter; Dubaj, Tibor; Rundén-Pran, Elise; Puntes, Victor; William, Nicola; von Briesen, Hagen; Wagner, Sylvia; Kapur, Nikil; Mariussen, Espen; Nelson, Andrew; Gabelova, A; Dusinska, Maria; Velten, Thomas; Knoll, Thorsten (Peer reviewed; Journal article, 2021)
      Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal‐free risk assessment of new chemicals and drugs. Microfluidic cell‐based devices ...
    • Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results 

      Møller, Peter; Azqueta, Amaya; Boutet-Robinet, Elisa; Koppen, Gudrun; Bonassi, Stefano; Milic, Mirta; Gajski, Goran; Costa, Solange; Teixeira, João Paulo; Pereira, Cristiana Costa; Dusinska, Maria; Godschalk, Roger; Brunborg, Gunnar; Gutzkow, Kristine Bjerve; Giovannelli, Lisa; Cooke, Marcus S.; Richling, Elke; Laffon, Blanca; Valdiglesias, Vanessa; Basaran, Nursen; Del Bo, Cristian; Zegura, Bojana; Novak, Matjaz; Stopper, Helga; Vodicka, Pavel; Vodenkova, Sona; de Andrade, Vanessa Moraes; Srámková, Monika; Gábelová, Alena; Collins, Andrew Richard; Langie, Sabine A.S. (Peer reviewed; Journal article, 2020)
      The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. ...
    • Multi-walled carbon nanotubes (NM401) induce ROS-mediated HPRT mutations in Chinese hamster lung fibroblasts 

      Rubio, Laura; El Yamani, Naouale; Kazimirova, Alena; Dusinska, Maria; Marcos, Ricard (Journal article; Peer reviewed, 2016)
    • Nanomedicine and epigenome. Possible health risks. 

      Smolkova, Bozena; Dusinska, Maria; Gábelová, Alena (Journal article; Peer reviewed, 2017)
    • Nanoparticles in the environment: assessment using the causal diagram approach 

      Smita, Suchi; Gupta, Shailendra K.; Bartonova, Alena; Dusinska, Maria; Gutleb, Arno; Rahman, Qamar (Journal article; Peer reviewed, 2012)