Blar i NILU Brage på forfatter "Dusinska, Maria"
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Effects of Titanium Dioxide Nanoparticles on the Hprt Gene Mutations in V79 Hamster Cells
Kazimirova, Alena; El Yamani, Naouale; Rubio, Laura; Garcia-Rodriguez, Alba; Barancokova, Magdalena; Marcos, Ricard; Dusinska, Maria (Peer reviewed; Journal article, 2020)The genotoxicity of anatase/rutile TiO2 nanoparticles (TiO2 NPs, NM105 at 3, 15 and 75 µg/cm2) was assessed with the mammalian in-vitro Hypoxanthine guanine phosphoribosyl transferase (Hprt) gene mutation test in Chinese ... -
Embedding Ethical Impact Assessment in Nanosafety Decision Support
Malsch, Ineke; Isigonis, Panagiotis; Dusinska, Maria; Bouman, Evert (Peer reviewed; Journal article, 2020)Nanotechnology is a key enabling technology, which is developing fast and influences many aspects of life. Nanomaterials are already included in a broad range of products and industrial sectors. Nanosafety issues are still ... -
Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives
Buociková, Verona; Rios-Mondragon, Ivan; Pilalis, Eleftherios; Chatziioannou, Aristotelis; Miklíková, Svetlana; Mego, Michal; Pajuste, Karlis; Rucins, Martins; El Yamani, Naouale; Longhin, Eleonora Marte; Sobolev, Arkadij; Freixanet, Muriel; Puntes, Victor; Plotniece, Aiva; Dusinska, Maria; Cimpan, Mihaela Roxana; Gábelová, Alena; Smolková, Božena (Peer reviewed; Journal article, 2020)Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. ... -
Epigenetics in breast cancer therapy—New strategies and future nanomedicine perspectives
Buociková, Verona; Rios Mondragon, Ivan; Pilalis, Eleftherios; Chatziioannou, Aristotelis; Miklíková, Svetlana; Mego, Michal; Pajuste, Karlis; Rucins, Martins; El Yamani, Naouale; Longhin, Eleonora Marte; Sobolev, Arkadij; Freixanet, Muriel; Puntes, Victor; Plotniece, Aiva; Dusinska, Maria; Cimpan, Mihaela Roxana; Gábelová, Alena; Smolková, Božena (Peer reviewed; Journal article, 2020)Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. ... -
European Registry of Materials: global, unique identifiers for (undisclosed) nanomaterials
van Rijn, Jeaphianne; Afantitis, Antreas; Culha, Mustafa; Dusinska, Maria; Exner, Thomas E.; Jeliazkova, Nina; Longhin, Eleonora Marta; Lynch, Iseult; Melagraki, Georgia; Nymark, Penny; Papadiamantis, Anastasios; Winkler, David A.; Yilmaz, Hulya; Willighagen, Egon (Peer reviewed; Journal article, 2022)Management of nanomaterials and nanosafety data needs to operate under the FAIR (findability, accessibility, interoperability, and reusability) principles and this requires a unique, global identifier for each nanomaterial. ... -
Evaluating the climate and air quality impacts of short-lived pollutants
Stohl, Andreas; Aamaas, Borgar; Amann, M; Baker, LH; Bellouin, N; Berntsen, Terje Koren; Boucher, O; Cherian, R; Collins, W; Daskalakis, N; Dusinska, Maria; Eckhardt, Sabine; Fuglestvedt, Jan S.; Harju, Mikael; Heyes, C; Hodnebrog, Øivind; Hao, J; Im, U; Kanakidou, M; Klimont, Z; Kupiainen, K; Law, KS; Lund, Marianne Tronstad; Maas, R; MacIntosh, CR; Myhre, Gunnar; Myriokefalitakis, S; Oliviè, Dirk Jan Leo; Quaas, J; Quennehen, B; Raut, JC; Rumbold, ST; Samset, Bjørn Hallvard; Schulz, M; Seland, Øyvind; Shine, KP; Skeie, Ragnhild Bieltvedt; Wang, S; Yttri, Karl Espen; Zhu, T (Journal article; Peer reviewed, 2015)This paper presents a summary of the work done within the European Union's Seventh Framework Programme project ECLIPSE (Evaluating the Climate and Air Quality Impacts of Short-Lived Pollutants). ECLIPSE had a unique ... -
Functionalized porous silica&maghemite core-shell nanoparticles for applications in medicine: design, synthesis, and immunotoxicity.
Zasońska, Beata A.; Liskova, Aurelia; Kuricová, Miroslava; Tulinská, Jana; Pop-Georgievsk, Ognen; Čiampor, Fedor; Vávra, Ivo; Dusinska, Maria; Ilavska, Silvia; Horváthová, Mira; Horák, Daniel (Journal article; Peer reviewed, 2016) -
Genetic variation associated with chromosomal aberration frequency: A genome‐wide association study
Niazi, Yasmeen; Thomsen, Hauke; Smolkova, Bozena; Vodickova, Ludmila; Vodenkova, Sona; Kroupa, Michal; Vymetalkova, Veronika; Kazimirova, Alena; Barancokova, Magdalena; Volkovova, Katarina; Staruchova, Marta; Hoffmann, Per; Nöthen, Markus M.; Dusinska, Maria; Musak, Ludovit; Vodicka, Pavel; Hemminki, Kari; Försti, Asta (Journal article; Peer reviewed, 2018) -
Genotoxic effects of occupational exposure to glass fibres - A human biomonitoring study
Ceppi, Marcello; Smolkova, Bozena; Staruchova, Marta; Kazimirova, Alena; Barancokova, Magdalena; Volkovova, Katarina; Collins, Andrew Richard; Kocan, Anton; Dzupinkova, Zuzana; Horska, Alexandra; Buocikova, Verona; Tulinska, Jana; Liskova, Aurelia; Mikusova, Miroslava Lehotska; Wsolova, Ladislava; Kuba, Daniel; Rundén-Pran, Elise; El Yamani, Naouale; Longhin, Eleonora Marta; Halasova, Erika; Kyrtopoulos, Soterios; Bonassi, Stefano; Dusinska, Maria (Peer reviewed; Journal article, 2023)As part of a large human biomonitoring study, we conducted occupational monitoring in a glass fibre factory in Slovakia. Shopfloor workers (n = 80), with a matched group of administrators in the same factory (n = 36), were ... -
Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment - A Review
Kohl, Yvonne; Rundén-Pran, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora Marte; Dusinska, Maria (Peer reviewed; Journal article, 2020)Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal ... -
Global and gene specific DNA methylation in breast cancer cells was not affected during epithelial-to-mesenchymal transition in vitro
Smolkova, B.; Miklikova, S.; Kajabova, V. H.; Babelova, A.; El Yamani, Naouale; Zduriencikova, M.; Fridrichova, I.; Zmetakova, I.; Krivulcik, T.; Kalinkova, L.; Matuskova, M.; Kucerova, M.; Dusinska, Maria (Journal article; Peer reviewed, 2016) -
Hazard assessment of nanomaterials using in vitro toxicity assays: Guidance on potential assay interferences and mitigating actions to avoid biased results
El Yamani, Naouale; Rundén-Pran, Elise; Varet, Julia; Beus, Maja; Dusinska, Maria; Fessard, Valerie; Moschini, Elisa; Serchi, Tommaso; Cimpan, Mihaela-Roxana; Lynch, Iseult; Vinković Vrček, ivana (Peer reviewed; Journal article, 2024)The movement towards an animal-free testing approach for risk assessment represents a key paradigm shift in toxicology. Risk assessment of engineered and anthropogenic nanoscale materials (NM) is dependent on reliable ... -
Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity
El Yamani, Naouale; Mariussen, Espen; Gromelski, Maciej; Wyrzykowska, Ewelina; Grabarek, Dawid; Puzyn, Tomasz; Tanasescu, Speranta; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2022)Hazard identification and safety assessment of the huge variety of nanomaterials (NMs), calls for robust and validated toxicity screening tests in combination with cheminformatics approaches to identify factors that can ... -
The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders
Milić, Mirta; Ceppi, Marcello; Bruzzone, Marco; Azqueta, Amaya; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine; Møller, Peter; Teixeira, João Paulo; Alija, Avdulla; Anderson, Diana; Andrade, Vanessa; Andreoli, Cristina; Asllani, Fisnik; Eyluel Bangkoglu, Ezgi; Barancokova, Magdalena; Basaran, Nursen; Boutet-Robinet, Elisa; Buschini, Annamaria; Cavallo, Delia; Costa Pererira, Cristina; Costa, Carla; Costa, Solange; Da Silva, Juliana; Del Bo’, Cristian; Dimitrijevic Sreckovic, Vesna; Djelic, Ninoslav; Dobrzynska, Malgorzata; Duracková, Zdenka; Dvorakova, Monika; Gajski, Goran; Galati, Serena; García Lima, Omar; Giovannelli, Lisa; Goroshinskaya, Irina A.; Grindel, Annemarie; Gützkow, Kristine Bjerve; Hernández, Alba; Hernandez, Carlos; Holven, Kirsten Bjørklund; Ibero-Baraibar, Idoia; Ottestad, Inger Olaug; Kadioglu, Ela; Kazimirova, Alena; Kuznetsova, Elena; Ladeira, Carina; Laffon, Blanca; Lamonaca, Palma; Lebailly, Pierre; Louro, Henriqueta; Cardoso, Tania Mandina; Marcon, Francesca; Marcos, Ricard; Moretti, Massimo; Moretti, Silvia; Najafzadeh, Mojgan; Nemeth, Zsuzsanna; Neri, Monica; Novotna, Bozena; Orlow, Irene; Paduchova, Zuzana; Pastor, Susana; Perdry, Hervé; Spremo-Potparević, Biljana; Ramadhani, Dwi; Riso, Patrizia; Rohr, Paula; Rojas, Emilio; Rossner, Pavel; Safar, Anna; Sardas, Semra; Silva, Maria João; Sirota, Nikolay; Smolkova, Bozena; Staruchova, Marta; Stetina, Rudolf; Stopper, Helga; Surikova, Ekaterina I.; Ulven, Stine Marie; Ursini, Cinzia Lucia; Valdiglesias, Vanessa; Valverde, Mahara; Vodička, Pavel; Volkovova, Katarina; Wagner, Karl-Heinz; Zivkovic, Lada; Dusinska, Maria; Collins, Andrew Richard; Bonassi, Stefano (Peer reviewed; Journal article, 2021)The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those ... -
Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model
Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2020)(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures ... -
High throughput toxicity screening and intracellular detection of nanomaterials
Collins, Andrew Richard; Balasubramanyam, Annangi; Rubio, Laura; Marcos, Ricard; Dorn, Marco; Merker, Carolin; Estrela-Lopis, Irina; Cimpan, Mihaela Roxana; Ibrahim, Mohamed; Cimpan, Emil; Ostermann, Melanie; Sauter, Alexander; El Yamani, Naouale; Shaposhnikov, Sergey; Chevillard, Sylvie; Paget, Vincent; Grall, Romain; Delic, Jozo; Goñi- de-Cerio, Felipe; Suarez-Merino, Blanca; Fessard, Valérie; Hogeveen, Kevin N; Fjellsbø, Lise Marie; Rundén-Pran, Elise; Brzicova, Tana; Topinka, Jan; João Silva, Maria; Leite, PE; Ribeiro, AR; Granjeiro, JM; Grafström, Roland; Prina-Mello, Adriele; Dusinska, Maria (Journal article; Peer reviewed, 2017) -
Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?
Dusinska, Maria; Tulinska, Jana; El Yamani, Naouale; Kuricova, Miroslava; Liskova, Aurelia; Rollerova, Eva; Rundén-Pran, Elise; Smolkova, Bozena (Journal article; Peer reviewed, 2017) -
Impact of nanosilver on various DNA lesions and HPRT gene mutations – effects of charge and surface coating
Huk, Anna; Izak-Nau, Emilia; El Yamani, Naouale; Uggerud, Hilde Thelle; Vadset, Marit; Zasonska, Beata; Duschl, Albert; Dusinska, Maria (Journal article; Peer reviewed, 2015) -
Impact of storage conditions and storage time on silver nanoparticles' physicochemical properties and implications for their biological effects
Izak-Nau, Emilia; Huk, Anna; Reidy, Bogumiła; Uggerud, Hilde Thelle; Vadset, Marit; Eiden, Stefanie; Voetz, Matthias; Himly, Martin; Duschl, Albert; Dusinska, Maria; Lynch, Iseult (Journal article; Peer reviewed, 2015) -
Improving Quality in Nanoparticle-Induced Cytotoxicity Testing by a Tiered Inter-Laboratory Comparison Study
Nelissen, Inge; Haase, Andrea; Anguissola, Sergio; Rocks, Louise; Jacobs, An; Willems, Hanny; Riebeling, Christian; Luch, Andreas; Piret, Jean-Pascal; Toussaint, Olivier; Trouiller, Benedicte; Lacroix, Ghislaine; Gutleb, Arno C.; Contal, Servane; Diabaté, Silvia; Weiss, Carsten; Lozano-Fernandez, Tamara; Gonzalez-Fernandez, Africa; Dusinska, Maria; Huk, Anna; Stone, Vicki; Kanase, Nilesh; Nocun, Marek; Stepnik, Maciej; Meschini, Stefania; Ammendolia, Maria Grazia; Lewinski, Nastassja; Riediker, Michael; Venturini, Marco; Benetti, Frederico; Topinka, Jan; Brzicova, Tana; Milani, Silvia; Rädler, Joachim; Salvati, Anna; Dawson, Kenneth A. (Peer reviewed; Journal article, 2020)The quality and relevance of nanosafety studies constitute major challenges to ensure their key role as a supporting tool in sustainable innovation, and subsequent competitive economic advantage. However, the number of ...