Blar i NILU Brage på forfatter "Dusinska, Maria"

Viser treff 41-60 av 79

    • An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform 

      Cheimarios, Nikolaos; Pem, Barbara; Tsoumanis, Andreas; Ilic, Krunoslav; Vrček, Ivana Vinković; Melagraki, Georgia; Bitounis, Dimitrios; Isigonis, Panagiotis; Dusinska, Maria; Lynch, Iseult; Demokritou, Philip; Afantitis, Antreas (Peer reviewed; Journal article, 2022)
      A freely available “in vitro dosimetry” web application is presented enabling users to predict the concentration of nanomaterials reaching the cell surface, and therefore available for attachment and internalization, from ...

    • In vitro evaluation of the genotoxicity of poly(anhydride) nanoparticles designed for oral drug delivery 

      Iglesias, T.; Dusinska, Maria; El Yamani, Naouale; Irache, J. M.; Azqueta, A.; de Cerain, A. López (Journal article; Peer reviewed, 2017)

    • In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment 

      El Yamani, Naouale; Collins, Andrew Richard; Rundén-Pran, Elise; Fjellsbø, Lise Marie; Shaposhnikov, Sergey; Zienolddiny, Shanbeh; Dusinska, Maria (Journal article; Peer reviewed, 2016)

    • In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials 

      Cardoso, Renato; Dusinska, Maria; Collins, Andrew Richard; Manjanatha, Mugamane; Pfuhler, Stefan; Registre, Marilyn; Elespuru, Rosalie K. (Peer reviewed; Journal article, 2022)
      The in vivo Comet assay measures the generation of DNA strand breaks under conditions in which the DNA will unwind and migrate to the anode in an electrophoresis assay, producing comet-like figures. Measurements are on ...

    • Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation 

      Mech, A.; Rasmussen, K.; Jantunen, P.; Aicher, L.; Alessandrelli, M.; Bernauer, U.; Bleeker, E. A. J.; Bouillard, J.; Di Prospero Fanghella, P.; Draisci, R.; Dusinska, Maria; Encheva, G.; Flament, G.; Haase, A.; Handzhiyski, Y.; Herzberg, F.; Huwyler, J.; Jacobsen, N.R.; Jeliazkov, V.; Jeliazkova, N.; Nymark, P.; Grafström, R.; Oomen, A. G.; Polci, M. L.; Riebeling, C.; Sandström, J.; Shivachev, B.; Stateva, S.; Tanasescu, S.; Tsekovska, R.; Wallin, Håkan; Wilks, M. F.; Zellmer, S.; Apostolova, M. D. (Journal article; Peer reviewed, 2018)
      This paper presents a comprehensive review of European Union (EU) legislation addressing the safety of chemical substances, and possibilities within each piece of legislation for applying grouping and read-across approaches ...

    • INTARESE. Revised integrated monitoring. 

      Liu, Hai-Ying; Bartonova, Alena; Dusinska, Maria (NILU OR;28/2010, Research report, 2010)
      The aim of this report is to summarize the results from (i) review of existing and planned environment and health monitoring programs (section 2.1); (ii) review of frameworks which are currently used in the integrated ...

    • Is the toxic potential of nanosilver dependent on its size? 

      Huk, Anna; Izak-Nau, Emilia; Reidy, Bogumila; Boyles, Matthew; Duschl, Albert; Lynch, Iseult; Dusinska, Maria (Journal article; Peer reviewed, 2014)

    • Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake 

      El Yamani, Naouale; Rubio, Laura; García-Rodríguez, Alba; Kažimírová, Alena; Rundén-Pran, Elise; Barančoková, Magdaléna; Marcos, Ricard; Dusinska, Maria (Peer reviewed; Journal article, 2022)
      The potential genotoxicity of titanium dioxide (TiO2) nanoparticles (NPs) is a conflictive topic because both positive and negative findings have been reported. To add clarity, we have carried out a study with two cell ...

    • Linking Nanomaterial-Induced Mitochondrial Dysfunction to Existing Adverse Outcome Pathways for Chemicals 

      Murugadoss, Sivakumar; Vrček, Ivana Vinković; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela-Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H. (Peer reviewed; Journal article, 2023)
      The Adverse Outcome Pathway (AOP) framework plays a crucial role in the paradigm shift of toxicity testing towards the development and use of new approach methodologies. AOPs developed for chemicals are in theory applicable ...

    • Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening 

      Kohl, Yvonne; Biehl, Margit; Spring, Sarah; Hesler, Michelle; Ogourtsov, Vladimir; Todorovic, Miomir; Owen, Joshua; Elje, Elisabeth; Kopecka, Kristina; Moriones, Oscar Hernando; Bastus, Neus G.; Simon, Peter; Dubaj, Tibor; Rundén-Pran, Elise; Puntes, Victor; William, Nicola; von Briesen, Hagen; Wagner, Sylvia; Kapur, Nikil; Mariussen, Espen; Nelson, Andrew; Gabelova, A; Dusinska, Maria; Velten, Thomas; Knoll, Thorsten (Peer reviewed; Journal article, 2021)
      Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal‐free risk assessment of new chemicals and drugs. Microfluidic cell‐based devices ...

    • The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials 

      El Yamani, Naouale; Rundén-Pran, Elise; Collins, Andrew Richard; Longhin, Eleonora Marta; Elje, Elisabeth; Hoet, Peter; Vrček, Ivana Vinković; Doak, Shareen H.; Fessard, Valérie; Dusinska, Maria (Peer reviewed; Journal article, 2022)
      The in vitro comet assay is a widely applied method for investigating genotoxicity of chemicals including engineered nanomaterials (NMs). A big challenge in hazard assessment of NMs is possible interference between the NMs ...

    • Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results 

      Møller, Peter; Azqueta, Amaya; Boutet-Robinet, Elisa; Koppen, Gudrun; Bonassi, Stefano; Milic, Mirta; Gajski, Goran; Costa, Solange; Teixeira, João Paulo; Pereira, Cristiana Costa; Dusinska, Maria; Godschalk, Roger; Brunborg, Gunnar; Gutzkow, Kristine Bjerve; Giovannelli, Lisa; Cooke, Marcus S.; Richling, Elke; Laffon, Blanca; Valdiglesias, Vanessa; Basaran, Nursen; Del Bo, Cristian; Zegura, Bojana; Novak, Matjaz; Stopper, Helga; Vodicka, Pavel; Vodenkova, Sona; de Andrade, Vanessa Moraes; Srámková, Monika; Gábelová, Alena; Collins, Andrew Richard; Langie, Sabine A.S. (Peer reviewed; Journal article, 2020)
      The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. ...

    • Multi-walled carbon nanotubes (NM401) induce ROS-mediated HPRT mutations in Chinese hamster lung fibroblasts 

      Rubio, Laura; El Yamani, Naouale; Kazimirova, Alena; Dusinska, Maria; Marcos, Ricard (Journal article; Peer reviewed, 2016)

    • Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival 

      Urbanova, Maria; Cihova, Marina; Buocikova, Verona; Slopovsky, Jan; Dubovan, Peter; Pindak, Daniel; Tomas, Miroslav; García-Bermejo, Laura; Rodríguez-Garrote, Mercedes; Earl, Julie; Kohl, Yvonne; Kataki, Agapi; Dusinska, Maria; Sainz Jr., Bruno; Smolkova, Bozena; Gabelova, Alena (Peer reviewed; Journal article, 2023)
      Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide, primarily due to its robust desmoplastic stroma and immunosuppressive tumor microenvironment (TME), which facilitate tumor progression and ...

    • Nanomedicine and epigenome. Possible health risks. 

      Smolkova, Bozena; Dusinska, Maria; Gábelová, Alena (Journal article; Peer reviewed, 2017)

    • Nanoparticles in the environment: assessment using the causal diagram approach 

      Smita, Suchi; Gupta, Shailendra K.; Bartonova, Alena; Dusinska, Maria; Gutleb, Arno; Rahman, Qamar (Journal article; Peer reviewed, 2012)

    • NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment 

      Afantitis, Antreas; Melagraki, Georgia; Isigonis, Panagiotis; Tsoumanis, Andreas; Varsou, Dimitra Danai; Valsami-Jones, Eugenia; Papadiamantis, Anastasios; Ellis, Laura-Jayne; Sarimveis, Haralambos; Doganis, Philip; Karatzas, Pantelis; Tsiros, Periklis; Liampa, Irene; Lobaskin, Vladimir; Greco, Dario; Serra, Angela; Kinaret, Pia Anneli Sofia; Saarimaki, Laura Aliisa; Grafström, Roland; Kohonen, Pekka; Nymark, Penny; Willighagen, Egon; Puzyn, Tomasz; Rybinska-Fryca, Anna; Lyubartsev, Alexander; Jensen, Keld Alstrup; Brandenburg, Gerit; Lofts, Stephen; Svendsen, Claus; Harrison, Samuel; Maier, Dieter; Tamm, Kaido; Janes, Jaak; Sikk, Lauri; Dusinska, Maria; Longhin, Eleonora Marte; Rundén-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Unger, Wolfgang; Radnik, Jörg; Tropsha, Alexander; Cohen, Yoram; Leszcynski, Jerzy; Hendren, Christine Ogilvie; Wiesner, Mark; Winkler, David; Suzuki, Noriyuki; Yoon, Tae Hyun; Choi, Jang-Sik; Gulumian, Mary; Lynch, Iseult (Peer reviewed; Journal article, 2020)
      Nanotechnology has enabled the discovery of a multitude of novel materials exhibiting unique physicochemical (PChem) properties compared to their bulk analogues. These properties have led to a rapidly increasing range of ...

    • New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project 

      Audebert, Marc; Assmann, Ann-Sophie; Azqueta, Amaya; Babica, Pavel; Benfenati, Emilio; Bortoli, Sylvie; Bouwman, Peter; Braeuning, Albert; Burgdorf, Tanja; Coumoul, Xavier; Debizet, Kloé; Dusinska, Maria (Peer reviewed; Journal article, 2023)
      Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can be detected by an established in vitro and in vivo battery ...

    • On the search for an intelligible comet assay descriptor 

      Møller, Peter; Loft, Steffen; Ersson, Clara; Koppen, Gudrun; Dusinska, Maria; Collins, Andrew Richard (Journal article; Peer reviewed, 2014)

    • An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity 

      Vodenkova, Sona; Azqueta, Amaya; Collins, Andrew Richard; Dusinska, Maria; Gaivao, Isabel; Møller, Peter; Opattová, Alena; Vodicka, Pavel; Godschalk, Roger W. L.; Langie, Sabine A.S. (Peer reviewed; Journal article, 2020)