Blar i NILU Brage på forfatter "Elje, Elisabeth"
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Advanced Respiratory Models for Hazard Assessment of Nanomaterials. Performance of Mono-, Co- and Tricultures
Camassa, Laura Maria Azzurra; Elje, Elisabeth; Mariussen, Espen; Longhin, Eleonora Marta; Dusinska, Maria; Zienolddiny-Narui, Shanbeh; Rundén-Pran, Elise (Peer reviewed; Journal article, 2022)Advanced in vitro models are needed to support next-generation risk assessment (NGRA), moving from hazard assessment based mainly on animal studies to the application of new alternative methods (NAMs). Advanced models must ... -
The colony forming efficiency assay for toxicity testing of nanomaterials – Modifications for higher-throughput
Rundén-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Elje, Elisabeth; Longhin, Eleonora Marta (Peer reviewed; Journal article, 2022)To cope with the high number of nanomaterials manufactured, it is essential to develop high-throughput methods for in vitro toxicity screening. At the same time, the issue with interference of the nanomaterial (NM) with ... -
Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials
Elje, Elisabeth; Mariussen, Espen; McFadden, Erin; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2023)For the next-generation risk assessment (NGRA) of chemicals and nanomaterials, new approach methodologies (NAMs) are needed for hazard assessment in compliance with the 3R’s to reduce, replace and refine animal experiments. ... -
Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model
Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2020)(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures ... -
Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening
Kohl, Yvonne; Biehl, Margit; Spring, Sarah; Hesler, Michelle; Ogourtsov, Vladimir; Todorovic, Miomir; Owen, Joshua; Elje, Elisabeth; Kopecka, Kristina; Moriones, Oscar Hernando; Bastus, Neus G.; Simon, Peter; Dubaj, Tibor; Rundén-Pran, Elise; Puntes, Victor; William, Nicola; von Briesen, Hagen; Wagner, Sylvia; Kapur, Nikil; Mariussen, Espen; Nelson, Andrew; Gabelova, A; Dusinska, Maria; Velten, Thomas; Knoll, Thorsten (Peer reviewed; Journal article, 2021)Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal‐free risk assessment of new chemicals and drugs. Microfluidic cell‐based devices ... -
The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials
El Yamani, Naouale; Rundén-Pran, Elise; Collins, Andrew Richard; Longhin, Eleonora Marta; Elje, Elisabeth; Hoet, Peter; Vrček, Ivana Vinković; Doak, Shareen H.; Fessard, Valérie; Dusinska, Maria (Peer reviewed; Journal article, 2022)The in vitro comet assay is a widely applied method for investigating genotoxicity of chemicals including engineered nanomaterials (NMs). A big challenge in hazard assessment of NMs is possible interference between the NMs ... -
Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform
Kohl, Yvonne; William, Nicola; Elje, Elisabeth; Backes, Nadine; Rothbauer, Mario; Srancikova, Annamaria; Rundén-Pran, Elise; El Yamani, Naouale; Korenstein, Rafi; Madi, Lea; Barbul, Alexander; Kozics, Katarina; Sramkova, Monika; Steenson, Karen; Gabelova, Alena; Ertl, Peter; Dusinska, Maria; Nelson, Andrew (Peer reviewed; Journal article, 2023)This study compares the performance and output of an electrochemical phospholipid membrane platform against respective in vitro cell-based toxicity testing methods using three toxicants of different biological action ... -
The comet assay applied to HepG2 liver spheroids
Elje, Elisabeth; Hesler, Michelle; Rundén-Pran, Elise; Mann, Pascal; Mariussen, Espen; Wagner, Sylvia; Dusinska, Maria; Kohl, Yvonne (Journal article; Peer reviewed, 2019)In accordance with the 3 Rs to reduce in vivo testing, more advanced in vitro models, moving from 2D monolayer to 3D cultures, should be developed for prediction of human toxicity of industrial chemicals and environmental ... -
Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles
Minelli, Caterina; Wywijas, Magdalena; Bartczak, Dorota; Cuello-Nuñez, Susana; Infante, Heidi Goenaga; Deumer, Jerome; Gollwitzer, Christian; Krumrey, Michael; Murphy, Karen E.; Johnson, Monique E.; Bustos, Antonio R. Montoro; Strenge, Ingo H.; Faure, Bertrand; Høghøj, Peter; Tong, Vivian; Burr, Loïc; Norling, Karin; Höök, Fredrik; Roesslein, Matthias; Kocic, Jovana; Hendriks, Lyndsey; Kestens, Vikram; Ramaye, Yannic; Lopez, Maria C. Contreras; Auclair, Guy; Mehn, Dora; Gilliland, Douglas; Potthoff, Annegret; Oelschlägel, Kathrin; Tentschert, Jutta; Jungnickel, Harald; Krause, Benjamin C.; Hachenberger, Yves U.; Reichardt, Philipp; Luch, Andreas; Whittaker, Thomas E.; Stevens, Molly M.; Gupta, Shalini; Singh, Akash; Lin, Fang-Hsin; Liu, Yi-Hung; Costa, Anna Luisa; Baldisserri, Carlo; Jawad, Rid; Andaloussi, Samir E. L.; Holme, Margaret N.; Lee, Tae Geol; Kwak, Minjeong; Kim, Jaeseok; Ziebel, Johanna; Guignard, Cedric; Cambier, Sebastien; Contal, Servane; Gutleb, Arno; Tatarkiewicz, Jan; Jankiewicz, Bartlomiej J.; Bartosewicz, Bartosz; Wu, Xiaochun; Fagan, Jeffrey A.; Elje, Elisabeth; Rundén-Pran, Elise; Dusinska, Maria; Kaur, Inder Preet; Price, David; Nesbitt, Ian; O'Reilly, Sarah; Peters, Ruud J. B.; Bucher, Guillaume; Coleman, Dennis; Harrison, Angela J.; Ghanem, Antoine; Gering, Anne; McCarron, Eileen; Fitzgerald, Niamh; Cornelis, Geert; Tuoriniemi, Jani; Sakai, Midori; Tsuchida, Hidehisa; Maguire, Ciarán; Prina-Mello, Adriele; Lawlor, Alan J.; Adams, Jessica; Schultz, Carolin L.; Constantin, Doru; Thanh, Nguyen Thi Kim; Tung, Le Duc; Panariello, Luca; Damilos, Spyridon; Gavriilidis, Asterios; Lynch, Iseult; Fryer, Benjamin; Quevedo, Ana Carrazco; Guggenheim, Emily; Briffa, Sophie; Valsami-Jones, Eugenia; Huang, Yuxiong; Keller, A.; Kinnunen, Virva-Tuuli; Perämäki, Siiri; Krpetic, Zeljka; Greenwood, Michael; Shard, Alexander G. (Peer reviewed; Journal article, 2022)We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, “Nanoparticle Populations” ...