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dc.contributor.authorLeung, Michael
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorWania, Frank
dc.contributor.authorPapp, Eszter Agnes
dc.contributor.authorHerzke, Dorte
dc.contributor.authorMahmud, Abdullah Al
dc.contributor.authorRoth, Daniel E
dc.date.accessioned2020-03-16T11:27:17Z
dc.date.available2020-03-16T11:27:17Z
dc.date.created2018-11-12T12:05:58Z
dc.date.issued2018
dc.identifier.citationExposure and Health. 2020, 12 79-87.en_US
dc.identifier.issn2451-9766
dc.identifier.urihttps://hdl.handle.net/11250/2646941
dc.description.abstractInformation about the human burdens of persistent organic pollutants (POPs) in low- and middle-income countries is limited. In particular, studies often include only a small subset of POPs. To address this data gap, we aimed to assess maternal-child exposures to POPs in Dhaka, Bangladesh. We quantified 16 organochlorine pesticides, 12 polychlorinated biphenyls, 21 brominated flame retardants, 18 per- and polyfluorinated alkyl substances, 2 polycyclic aromatic hydrocarbons, and short-chain chlorinated paraffins in 18 pooled samples of human cord blood from 90 mother–infant pairs living in Dhaka, Bangladesh (2014–2015). In all pooled samples, we detected high levels of p,p′-DDT (median 81.6 ng/g lipid) and its metabolites p,p′-DDE and p,p′-DDD (median 551 and 10.7 ng/g lipid, respectively), where the p,p′-DDE/p,p′-DDT ratio ranged from 2.9 to 9.8 indicating recent dichlorodiphenyltrichloroethane (DDT) exposure. We also detected acenaphthene, decabromodiphenyl ethane, o,p′-DDT, o,p′-DDE, hexachlorobenzene, β-hexachlorocyclohexane, hexabromobenzene, and perfluorooctanoic acid in a subset of samples. For the other 59 target compounds, concentrations were below the limits of detection, despite using ultra-trace analytical methodology. No trends were observed when stratifying the analyses of detected POP concentrations by maternal age, maternal body mass index, or large fish consumption. These findings highlight recent DDT exposure in Dhaka, but the overall POP burden was otherwise low in this sample of pregnant women/newborns. Future monitoring efforts should focus on newly detected POPs for which burdens may be increasing due to ongoing industrialization in Bangladesh.
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMaternal-Child Exposures to Persistent Organic Pollutants in Dhaka, Bangladeshen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s) 2018en_US
dc.source.pagenumber79-87en_US
dc.source.volume12en_US
dc.source.journalExposure and Healthen_US
dc.identifier.doi10.1007/s12403-018-0286-x
dc.identifier.cristin1629406
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.fulltextoriginal
cristin.qualitycode1


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