Browsing NILU Brage by Journals "Mutation Research. Genetic Toxicology and Environmental Mutagenesis"

Now showing items 1-4 of 4

    • Do cytotoxicity and cell death cause false positive results in the in vitro comet assay? 

      Azqueta, Amaya; Stopper, Helga; Zegura, Bojana; Dusinska, Maria; Møller, Peter (Peer reviewed; Journal article, 2022)
      The comet assay is used to measure DNA damage induced by chemical and physical agents. High concentrations of test agents may cause cytotoxicity or cell death, which may give rise to false positive results in the comet ...

    • Genotoxic effects of occupational exposure to glass fibres - A human biomonitoring study 

      Ceppi, Marcello; Smolkova, Bozena; Staruchova, Marta; Kazimirova, Alena; Barancokova, Magdalena; Volkovova, Katarina; Collins, Andrew Richard; Kocan, Anton; Dzupinkova, Zuzana; Horska, Alexandra; Buocikova, Verona; Tulinska, Jana; Liskova, Aurelia; Mikusova, Miroslava Lehotska; Wsolova, Ladislava; Kuba, Daniel; Rundén-Pran, Elise; El Yamani, Naouale; Longhin, Eleonora Marta; Halasova, Erika; Kyrtopoulos, Soterios; Bonassi, Stefano; Dusinska, Maria (Peer reviewed; Journal article, 2023)
      As part of a large human biomonitoring study, we conducted occupational monitoring in a glass fibre factory in Slovakia. Shopfloor workers (n = 80), with a matched group of administrators in the same factory (n = 36), were ...

    • Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake 

      El Yamani, Naouale; Rubio, Laura; García-Rodríguez, Alba; Kažimírová, Alena; Rundén-Pran, Elise; Barančoková, Magdaléna; Marcos, Ricard; Dusinska, Maria (Peer reviewed; Journal article, 2022)
      The potential genotoxicity of titanium dioxide (TiO2) nanoparticles (NPs) is a conflictive topic because both positive and negative findings have been reported. To add clarity, we have carried out a study with two cell ...

    • Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT) 

      Pfuhler, Stefan; van Benthem, Jan; Curren, Rodger; Doak, Shareen H.; Dusinska, Maria; Hayashi, Makoto; Heflich, Robert H.; Kidd, Darren; Kirkland, David; Luan, Yang; Ouedraogo, Gladys; Reisinger, Kerstin; Sofuni, Toshio; van Acker, Frederique; Yang, Ying; Corvi, Raffaella (Peer reviewed; Journal article, 2020)
      Use of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress ...