Browsing NILU Brage by Journals "Nanomaterials"

Now showing items 1-12 of 12

    • Advanced Respiratory Models for Hazard Assessment of Nanomaterials. Performance of Mono-, Co- and Tricultures 

      Camassa, Laura Maria Azzurra; Elje, Elisabeth; Mariussen, Espen; Longhin, Eleonora Marta; Dusinska, Maria; Zienolddiny-Narui, Shanbeh; Rundén-Pran, Elise (Peer reviewed; Journal article, 2022)
      Advanced in vitro models are needed to support next-generation risk assessment (NGRA), moving from hazard assessment based mainly on animal studies to the application of new alternative methods (NAMs). Advanced models must ...

    • Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials 

      Elje, Elisabeth; Mariussen, Espen; McFadden, Erin; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2023)
      For the next-generation risk assessment (NGRA) of chemicals and nanomaterials, new approach methodologies (NAMs) are needed for hazard assessment in compliance with the 3R’s to reduce, replace and refine animal experiments. ...

    • Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms? 

      Gupta, Suchi Smita; Singh, Krishna P.; Gupta, Shailendra; Dusinska, Maria; Rahman, Qamar (Peer reviewed; Journal article, 2022)
      During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 ...

    • Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance 

      Lynch, Iseult; Afantitis, Antreas; Greco, Dario; Dusinska, Maria; Banares, Miguel A.; Melagraki, Georgia (Others, 2021)

    • Effects of Titanium Dioxide Nanoparticles on the Hprt Gene Mutations in V79 Hamster Cells 

      Kazimirova, Alena; El Yamani, Naouale; Rubio, Laura; Garcia-Rodriguez, Alba; Barancokova, Magdalena; Marcos, Ricard; Dusinska, Maria (Peer reviewed; Journal article, 2020)
      The genotoxicity of anatase/rutile TiO2 nanoparticles (TiO2 NPs, NM105 at 3, 15 and 75 µg/cm2) was assessed with the mammalian in-vitro Hypoxanthine guanine phosphoribosyl transferase (Hprt) gene mutation test in Chinese ...

    • Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment - A Review 

      Kohl, Yvonne; Rundén-Pran, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora Marte; Dusinska, Maria (Peer reviewed; Journal article, 2020)
      Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal ...

    • Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model 

      Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2020)
      (1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures ...

    • Improving Quality in Nanoparticle-Induced Cytotoxicity Testing by a Tiered Inter-Laboratory Comparison Study 

      Nelissen, Inge; Haase, Andrea; Anguissola, Sergio; Rocks, Louise; Jacobs, An; Willems, Hanny; Riebeling, Christian; Luch, Andreas; Piret, Jean-Pascal; Toussaint, Olivier; Trouiller, Benedicte; Lacroix, Ghislaine; Gutleb, Arno C.; Contal, Servane; Diabaté, Silvia; Weiss, Carsten; Lozano-Fernandez, Tamara; Gonzalez-Fernandez, Africa; Dusinska, Maria; Huk, Anna; Stone, Vicki; Kanase, Nilesh; Nocun, Marek; Stepnik, Maciej; Meschini, Stefania; Ammendolia, Maria Grazia; Lewinski, Nastassja; Riediker, Michael; Venturini, Marco; Benetti, Frederico; Topinka, Jan; Brzicova, Tana; Milani, Silvia; Rädler, Joachim; Salvati, Anna; Dawson, Kenneth A. (Peer reviewed; Journal article, 2020)
      The quality and relevance of nanosafety studies constitute major challenges to ensure their key role as a supporting tool in sustainable innovation, and subsequent competitive economic advantage. However, the number of ...

    • An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform 

      Cheimarios, Nikolaos; Pem, Barbara; Tsoumanis, Andreas; Ilic, Krunoslav; Vrček, Ivana Vinković; Melagraki, Georgia; Bitounis, Dimitrios; Isigonis, Panagiotis; Dusinska, Maria; Lynch, Iseult; Demokritou, Philip; Afantitis, Antreas (Peer reviewed; Journal article, 2022)
      A freely available “in vitro dosimetry” web application is presented enabling users to predict the concentration of nanomaterials reaching the cell surface, and therefore available for attachment and internalization, from ...

    • Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation 

      Dubaj, Tibor; Kozics, Katarina; Srámková, Monika; Manova, Alena; Bastus, Neus G.; Moriones, Oscar H.; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise; Puntes, Victor; Nelson, Andrew; Gábelová, Alena; Simon, Peter (Peer reviewed; Journal article, 2022)
      Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies ...

    • Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation 

      Mikusova, Miroslava Lehotska; Busova, Milena; Tulinska, Jana; Masanova, Vlasta; Liskova, Aurelia; Uhnakova, Iveta; Dusinska, Maria; Krivosikova, Zora; Rollerova, Eva; Alacova, Radka; Wsolova, Ladislava; Horvathova, Mira; Szabova, Michaela; Lukan, Norbert; Vecera, Zbynek; Coufalik, Pavel; Krumal, Kamil; Alexa, Lukas; Thon, Vojtech; Piler, Pavel; Buchtova, Marcela; Vrlikova, Lucie; Moravec, Pavel; Mikuska, Pavel (Peer reviewed; Journal article, 2023)
      Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects ...

    • Toward Standardization of a Lung New Approach Model for Toxicity Testing of Nanomaterials 

      Elje, Elisabeth; Camassa, Laura Maria Azzurra; Shaposhnikov, Sergey; Anmarkrud, Kristine Haugen; Skare, Øivind; Nilsen, Asbjørn Magne; Zienolddiny, Shanbeh; Rundén-Pran, Elise (Peer reviewed; Journal article, 2024)
      This study represents an attempt toward the standardization of pulmonary NAMs and the development of a novel approach for toxicity testing of nanomaterials. Laboratory comparisons are challenging yet essential for identifying ...