Blar i NILU Brage på forfatter "Dusinska, Maria"
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Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation
Dubaj, Tibor; Kozics, Katarina; Srámková, Monika; Manova, Alena; Bastus, Neus G.; Moriones, Oscar H.; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise; Puntes, Victor; Nelson, Andrew; Gábelová, Alena; Simon, Peter (Peer reviewed; Journal article, 2022)Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies ... -
Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform
Kohl, Yvonne; William, Nicola; Elje, Elisabeth; Backes, Nadine; Rothbauer, Mario; Srancikova, Annamaria; Rundén-Pran, Elise; El Yamani, Naouale; Korenstein, Rafi; Madi, Lea; Barbul, Alexander; Kozics, Katarina; Sramkova, Monika; Steenson, Karen; Gabelova, Alena; Ertl, Peter; Dusinska, Maria; Nelson, Andrew (Peer reviewed; Journal article, 2023)This study compares the performance and output of an electrochemical phospholipid membrane platform against respective in vitro cell-based toxicity testing methods using three toxicants of different biological action ... -
Refining in vitro models for nanomaterial exposure to cells and tissues
Guggenheim, Emily J.; Milani, Silvia; Röttgermann, Peter J. F.; Dusinska, Maria; Saout, Christelle; Salvati, Anna; Rädler, Joachim O.; Lynch, Iseult (Journal article; Peer reviewed, 2018) -
Safe(r) by design implementation in the nanotechnology industry
Jiménes, Araceli Sánchez; Puelles, Raquel; Pérez-Fernández, Marta; Gómez-Fernández, Paloma; Barruetabena, Leire; Jacobsen, Nicklas Raun; Suarez-Merino, Blanca; Micheletti, Christian; Manier, Nicolas; Trouiller, Benedicte; Navas, José Maria; Kalman, Judit; Salieri, Beatrice; Hischier, Roland; Handzhiyski, Yordan; Apostolova, Margarita D.; Hadrup, Niels; Bouillard, Jaques; Oudart, Yohan; Merino, Cesar; Garcia, Erika; Liguori, Biase; Sabella, Stefania; Rose, Jerome; Maison, Armand; Galea, Karen S.; Kelly, Sean; Stepankova, Sandra; Mouneyrac, Catherine; Barrick, Andrew; Chatel, Amelie; Dusinska, Maria; Rundén-Pran, Elise; Mariussen, Espen; Bressot, Christophe; Aguerre-Chariol, Olivier; Shandilya, Neeraj; Goede, Henk; Gomez-Cordon, Julio; Simar, Sophie; Nesslany, Fabrice; Jensen, Keld Alstrup; van Tongeren, Martie; Llopis, Isabel Rodriguez (Peer reviewed; Journal article, 2020)The implementation of Safe(r) by Design (SbD) in industrial innovations requires an integrated approach where the human, environmental and economic impact of the SbD measures is evaluated across and throughout the nanomaterial ... -
Safety assessment of titanium dioxide (E171) as a food additive
Younes, Maged; Aquilina, Gabriele; Castle, Laurence; Engel, Karl-Heinz; Fowler, Paul; Fernandez, Maria Jose Frutos; Fürst, Peter; Gundert-Remy, Ursula; Gürtler, Rainer; Husøy, Trine; Manco, Melania; Mennes, Wim; Moldeus, Peter; Passamonti, Sabina; Shah, Romina; Waalkens-Berendsen, Ine; Wölfle, Detlef; Corsini, Emanuela; Cubadda, Francesco; De Groot, Didima; FitzGerald, Rex; Gunnare, Sara; Gutleb, Arno C.; Mast, Jan; Mortensen, Alicja; Oomen, Agnes; Piersma, Aldert; Plichta, Veronika; Ulbrich, Beate; Van Loveren, Henk; Benford, Diane; Bignami, Margherita; Bolognesi, Claudia; Crebelli, Riccardo; Dusinska, Maria; Marcon, Francesca; Nielsen, Elsa; Schlatter, Josef; Vleminckx, Christiane; Barmaz, Stefania; Carfi, Maria; Civitella, Consuelo; Giarola, Alessandra; Rincon, Ana Maria; Serafimova, Rositsa; Smeraldi, Camilla; Tarazona, Jose; Tard, Alexandra; Wright, Matthew (Peer reviewed; Journal article, 2021)The present opinion deals with an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by the Panel to be reliable, including data obtained with TiO2 ... -
Safety-by-design and engineered nanomaterials: the need to move from theory to practice
Trump, Benjamin D.; Antunes, Dalila; Palma-Oliveira, José; Nelson, Andrew; Hudecova, Alexandra Misci; Rundén-Pran, Elise; Dusinska, Maria; Gispert, Ignasi; Resch, Susanne; Alfaro-Serrano, Beatriz; Afantitis, Antreas; Melagraki, Georgia; Tse, Edmund C. M.; Trump, Josh; Kohl, Yvonne; Linkov, Igor (Peer reviewed; Journal article, 2023)As the governance of engineered nanomaterials (ENMs) evolves, innovations in the prevention, mitigation, management, and transfer of risk shape discussion of how nanotechnology may mature and reach various marketplaces. ... -
A strategy towards the generation of testable adverse outcome pathways for nanomaterials
Murugadoss, Sivakumar; Vrcek, Ivana Vinkovic; Pem, Barbara; Jagiello, Karolina; Judzinska, Beata; Sosnowska, Anita; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Dusinska, Maria; Cimpan, Mihaela-Roxana; Fessard, Valérie; Hoet, Peter H. (Peer reviewed; Journal article, 2021)Manufactured nanomaterials (NMs) are increasingly used in a wide range of industrial applications leading to a constant increase in the market size of nano-enabled products. The increased production and use of NMs are ... -
Technical recommendations to perform the alkaline standard and enzyme-modified comet assay in human biomonitoring studies
Azqueta, Amaya; Muruzabal, Damian; Boutet-Robinet, Elisa; Milic, Mirta; Dusinska, Maria; Brunborg, Gunnar; Møller, Peter; Collins, Andrew R. (Journal article; Peer reviewed, 2019) -
The comet assay applied to HepG2 liver spheroids
Elje, Elisabeth; Hesler, Michelle; Rundén-Pran, Elise; Mann, Pascal; Mariussen, Espen; Wagner, Sylvia; Dusinska, Maria; Kohl, Yvonne (Journal article; Peer reviewed, 2019)In accordance with the 3 Rs to reduce in vivo testing, more advanced in vitro models, moving from 2D monolayer to 3D cultures, should be developed for prediction of human toxicity of industrial chemicals and environmental ... -
The effect of core and lanthanide ion dopants in sodium fluoride-based nanocrystals on phagocytic activity of human blood leukocytes
Sojka, Bartlomiej; Liskova, Aurelia; Banski, Mateusz; Misiewicz, Jan; Dusinska, Maria; Horvathova, Mira; Ilavska, Silvia; Szabova, Michaela; Rollerova, Eva; Podhorodecki, Artur; Tulinska, Jana (Journal article; Peer reviewed, 2017) -
The effect of core and lanthanide ion dopants in sodium fluoride-based nanocrystals on phagocytic activity of human blood leukocytes
Sojka, Bartlomiej; Liskova, Aurelia; Kuricová, Miroslava; Banski, Mateusz; Misiewicz, Jan; Dusinska, Maria; Horváthová, Mira; Ilavska, Silvia; Szabova, Michaela; Rollerova, Eva; Podhorodecki, Artur; Tulinská, Jana (Journal article; Peer reviewed, 2017) -
The use of the comet assay for the evaluation of the genotoxicity of nanomaterials
Azqueta, Amaya; Dusinska, Maria (Journal article; Peer reviewed, 2015) -
Thermodynamic parameters at bio-nano interface and nanomaterial toxicity: A case study on BSA interaction with ZnO, SiO2 and TiO2
Precupas, Aurica; Gheorghe, Daniela; Botea-Petcu, Alina; Leonties, Anca Ruxandra; Sandu, Romica; Popa, Vlad Tudor; Mariussen, Espen; El Yamani, Naouale; Rundén-Pran, Elise; Dumit, Veronica; Xue, Ying; Cimpan, Mihaela Roxana; Dusinska, Maria; Haase, Andrea; Tanasescu, Speranta (Peer reviewed; Journal article, 2020)Understanding nanomaterial (NM)–protein interactions is a key issue in defining the bioreactivity of NMs with great impact for nanosafety. In the present work, the complex phenomena occurring at the bio/nano interface were ... -
Thymidine Kinase+/− Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials
Chen, Tao; Dusinska, Maria; Elespuru, Rosalie K. (Peer reviewed; Journal article, 2022)The methods outlined here are part of a series of papers designed specifically for genotoxicity assessment of nanomaterials (NM). Common Considerations such as NM characterization, sample preparation and dose selection, ... -
Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation
Mikusova, Miroslava Lehotska; Busova, Milena; Tulinska, Jana; Masanova, Vlasta; Liskova, Aurelia; Uhnakova, Iveta; Dusinska, Maria; Krivosikova, Zora; Rollerova, Eva; Alacova, Radka; Wsolova, Ladislava; Horvathova, Mira; Szabova, Michaela; Lukan, Norbert; Vecera, Zbynek; Coufalik, Pavel; Krumal, Kamil; Alexa, Lukas; Thon, Vojtech; Piler, Pavel; Buchtova, Marcela; Vrlikova, Lucie; Moravec, Pavel; Mikuska, Pavel (Peer reviewed; Journal article, 2023)Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects ... -
Towards a Consensus View on Understanding Nanomaterials Hazards and Managing Exposure: Knowledge Gaps and Recommendations
Hunt, Geoffrey; Lynch, Iseult; Cassee, Flemming R.; Handy, Richard D.; Fernandes, Teresa F.; Berges, Markus; Kuhlbusch, Thomas; Dusinska, Maria; Riediker, Michael (Journal article; Peer reviewed, 2013)The aim of this article is to present an overview of salient issues of exposure, characterisation and hazard assessment of nanomaterials as they emerged from the consensus-building of experts undertaken within the four ... -
Treatment with silver nanoparticles delays repair of X-ray induced DNA damage in HepG2 cells
Wojewódzka, Maria; Lankoff, Anna; Dusinska, Maria; Brunborg, Gunnar; Czerwinska, Jolanta; Iwanenko, Teresa; Stepkowski, Tomasz; Szumiel, Irena; Kruszewski, Marcin (Peer reviewed; Journal article, 2011) -
Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT)
Pfuhler, Stefan; van Benthem, Jan; Curren, Rodger; Doak, Shareen H.; Dusinska, Maria; Hayashi, Makoto; Heflich, Robert H.; Kidd, Darren; Kirkland, David; Luan, Yang; Ouedraogo, Gladys; Reisinger, Kerstin; Sofuni, Toshio; van Acker, Frederique; Yang, Ying; Corvi, Raffaella (Peer reviewed; Journal article, 2020)Use of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress ... -
Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles
Minelli, Caterina; Wywijas, Magdalena; Bartczak, Dorota; Cuello-Nuñez, Susana; Infante, Heidi Goenaga; Deumer, Jerome; Gollwitzer, Christian; Krumrey, Michael; Murphy, Karen E.; Johnson, Monique E.; Bustos, Antonio R. Montoro; Strenge, Ingo H.; Faure, Bertrand; Høghøj, Peter; Tong, Vivian; Burr, Loïc; Norling, Karin; Höök, Fredrik; Roesslein, Matthias; Kocic, Jovana; Hendriks, Lyndsey; Kestens, Vikram; Ramaye, Yannic; Lopez, Maria C. Contreras; Auclair, Guy; Mehn, Dora; Gilliland, Douglas; Potthoff, Annegret; Oelschlägel, Kathrin; Tentschert, Jutta; Jungnickel, Harald; Krause, Benjamin C.; Hachenberger, Yves U.; Reichardt, Philipp; Luch, Andreas; Whittaker, Thomas E.; Stevens, Molly M.; Gupta, Shalini; Singh, Akash; Lin, Fang-Hsin; Liu, Yi-Hung; Costa, Anna Luisa; Baldisserri, Carlo; Jawad, Rid; Andaloussi, Samir E. L.; Holme, Margaret N.; Lee, Tae Geol; Kwak, Minjeong; Kim, Jaeseok; Ziebel, Johanna; Guignard, Cedric; Cambier, Sebastien; Contal, Servane; Gutleb, Arno; Tatarkiewicz, Jan; Jankiewicz, Bartlomiej J.; Bartosewicz, Bartosz; Wu, Xiaochun; Fagan, Jeffrey A.; Elje, Elisabeth; Rundén-Pran, Elise; Dusinska, Maria; Kaur, Inder Preet; Price, David; Nesbitt, Ian; O'Reilly, Sarah; Peters, Ruud J. B.; Bucher, Guillaume; Coleman, Dennis; Harrison, Angela J.; Ghanem, Antoine; Gering, Anne; McCarron, Eileen; Fitzgerald, Niamh; Cornelis, Geert; Tuoriniemi, Jani; Sakai, Midori; Tsuchida, Hidehisa; Maguire, Ciarán; Prina-Mello, Adriele; Lawlor, Alan J.; Adams, Jessica; Schultz, Carolin L.; Constantin, Doru; Thanh, Nguyen Thi Kim; Tung, Le Duc; Panariello, Luca; Damilos, Spyridon; Gavriilidis, Asterios; Lynch, Iseult; Fryer, Benjamin; Quevedo, Ana Carrazco; Guggenheim, Emily; Briffa, Sophie; Valsami-Jones, Eugenia; Huang, Yuxiong; Keller, A.; Kinnunen, Virva-Tuuli; Perämäki, Siiri; Krpetic, Zeljka; Greenwood, Michael; Shard, Alexander G. (Peer reviewed; Journal article, 2022)We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, “Nanoparticle Populations” ...