Browsing NILU Brage by Author "Dusinska, Maria"

Now showing items 1-20 of 87

    • Advanced Respiratory Models for Hazard Assessment of Nanomaterials. Performance of Mono-, Co- and Tricultures 

      Camassa, Laura Maria Azzurra; Elje, Elisabeth; Mariussen, Espen; Longhin, Eleonora Marta; Dusinska, Maria; Zienolddiny-Narui, Shanbeh; Rundén-Pran, Elise (Peer reviewed; Journal article, 2022)
      Advanced in vitro models are needed to support next-generation risk assessment (NGRA), moving from hazard assessment based mainly on animal studies to the application of new alternative methods (NAMs). Advanced models must ...

    • The alamar blue assay in the context of safety testing of nanomaterials 

      Longhin, Eleonora Marta; El Yamani, Naouale; Rundén-Pran, Elise; Dusinska, Maria (Peer reviewed; Journal article, 2022)
      The Alamar Blue (AB) assay is widely used to investigate cytotoxicity, cell proliferation and cellular metabolic activity within different fields of toxicology. The use of the assay with nanomaterials (NMs) entails specific ...

    • Approaches to integrated monitoring for environmental health impact assessment 

      Liu, Hai-Ying; Bartonova, Alena; Pascal, Mathilde; Smolders, Roel; Skjetne, Erik; Dusinska, Maria (Journal article; Peer reviewed, 2012)

    • Associations between environmental factors and incidence of cutaneous melanoma. Review. 

      Volkovova, Katarina; Bilanicova, Dagmar; Bartonova, Alena; Letašiová, Silvia; Dusinska, Maria (Journal article; Peer reviewed, 2012)

    • Author Correction: DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death (Scientific Reports, (2021), 11, 1, (16793), 10.1038/s41598-021-95976-7) 

      Bonassi, Stefano; Ceppi, Marcello; Møller, Peter; Azqueta, Amaya; Milić, Mirta; Neri, Monica; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine A. S.; Teixeira, João Paulo; Bruzzone, Marco; Da Silva, Juliana; Benedetti, Danieli; Cavallo, Delia; Ursini, Cinzia Lucia; Giovannelli, Lisa; Moretti, Silvia; Riso, Patrizia; Del Bo’, Cristian; Russo, Patrizia; Dobrzyńska, Malgorzata; Goroshinskaya, Irina A.; Surikova, Ekaterina I.; Staruchova, Marta; Barančokova, Magdalena; Volkovova, Katarina; Kažimirova, Alena; Smolkova, Bozena; Laffon, Blanca; Valdiglesias, Vanessa; Pastor, Susana; Marcos, Ricard; Hernández, Alba; Gajski, Goran; Spremo-Potparević, Biljana; Živković, Lada; Boutet-Robinet, Elisa; Perdry, Hervé; Lebailly, Pierre; Perez, Carlos L.; Basaran, Nursen; Nemeth, Zsuzsanna; Safar, Anna; Dusinska, Maria; Collins, Andrew Richard (Journal article, 2021)

    • Bladder cancer, a review of the environmental risk factors 

      Letašiová, Silvia; Medved'ová, Alžbeta; Šovčíková, Andrea; Dusinska, Maria; Volkovova, Katarina; Mosoiu, Claudia; Bartonova, Alena (Journal article; Peer reviewed, 2012)

    • Cancer risk and the complexity of the interactions between environmental and host factors: HENVINET interactive diagrams as simple tools for exploring and understanding the scientific evidence 

      Merlo, Domenico Franco; Filiberti, Rosangela; Kobernus, Michael John; Bartonova, Alena; Gamulin, Marija; Ferencic, Zeljko; Dusinska, Maria; Fucic, Alexsandra (Journal article; Peer reviewed, 2012)

    • Collection and storage of human white blood cells for analysis of DNA damage and repair activity using the comet assay in molecular epidemiology studies 

      Møller, Peter; Bankoglu, Ezgi Eyluel; Stopper, Helga; Giovannelli, Lisa; Ladeira, Carina; Koppen, Gudrun; Gajski, Goran; Collins, Andrew Richard; Valdiglesias, Vanessa; Laffon, Blanca; Boutet-Robinet, Elisa; Perdry, Hervé; Del Bo, Cristian; Langie, Sabine A.S.; Dusinska, Maria; Azqueta, Amaya (Peer reviewed; Journal article, 2021)
      DNA damage and repair activity are often assessed in blood samples from humans in different types of molecular epidemiology studies. However, it is not always feasible to analyse the s#38les on the day of collection without ...

    • The comet assay in animal models: From bugs to whales – (Part 1 Invertebrates) 

      Gajski, Goran; Žegura, Bojana; Ladeira, Carina; Pourrut, Bertrand; Del Bo, Cristian; Novak, Matjaž; Srámková, Monika; Milić, Mirta; Gutzkow, Kristine Bjerve; Costa, Solange; Dusinska, Maria; Brunborg, Gunnar; Collins, Andrew Richard (Peer reviewed; Journal article, 2019)

    • Common Considerations for Genotoxicity Assessment of Nanomaterials 

      Elespuru, Rosalie K.; Doak, Shareen H.; Collins, Andrew Richard; Dusinska, Maria; Pfuhler, Stefan; Manjanatha, Mugamane; Cardoso, Renato M.S.; Chen, Connie L. (Peer reviewed; Journal article, 2022)
      Genotoxicity testing is performed to determine potential hazard of a chemical or agent for direct or indirect DNA interaction. Testing may be a surrogate for assessment of heritable genetic risk or carcinogenic risk. Testing ...

    • CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials 

      Zouraris, Dimitrios; Mavrogiorgis, Angelos; Tsoumanis, Andreas; Saarimaki, Laura Aliisa; del Giudice, Giusy; Federico, Antonio; Serra, Angela; Greco, Dario; Rouse, Ian; Subbotina, Julia; Lobaskin, Vladimir; Jagiello, Karolina; Ciura, Krzesimir; Judzinska, Beata; Mikolajczyk, Alicja; Sosnowska, Anita; Puzyn, Tomasz; Gulumian, Mary; Wepener, Victor; Martinez, Diego S. T.; Petry, Romana; El Yamani, Naouale; Rundén-Pran, Elise; Murugadoss, Sivakumar; Shaposhnikov, Sergey; Minadakis, Vasileios; Tsiros, Periklis; Sarimveis, Harry; Longhin, Eleonora Marta; Sengupta, Tanima; Olsen, Ann-Karin Hardie; Skakalova, Viera; Hutar, Peter; Dusinska, Maria; Papadiamantis, Anastasios; Gheorghe, L. Cristiana; Reilly, Katie; Brun, Emilie; Ullah, Sami; Cambier, Sebastien; Serchi, Tommaso; Tamm, Kaido; Lorusso, Candida; Dondero, Francesco; Melagrakis, Evangelos; Fraz, Muhammad Moazam; Melagraki, Georgia; Lynch, Iseult; Afantitis, Antreas (Peer reviewed; Journal article, 2025)
      The CompSafeNano project, a Research and Innovation Staff Exchange (RISE) project funded under the European Union's Horizon 2020 program, aims to advance the safety and innovation potential of nanomaterials (NMs) by ...

    • Copper Oxide Nanoparticles Stimulate the Immune Response and Decrease Antioxidant Defense in Mice After Six-Week Inhalation 

      Tulinska, Jana; Mikusova, Miroslava Lehotska; Liskova, Aurelia; Busova, Milena; Masanova, Vlasta; Uhnakova, Iveta; Rollerova, Eva; Alacova, Radka; Krivosikova, Zora; Wsolova, Ladislava; Dusinska, Maria; Horváthová, Mira; Szabova, Michaela; Lukan, Norbert; Stuchlikova, Martina; Kuba, Daniel; Vecera, Zbynek; Coufalik, Pavel; Krumal, Kamil; Alexa, Lukas; Vrlikova, Lucie; Buchtova, Marcela; Dumkova, Jana; Piler, Pavel; Thon, Vojtech; Mikuska, Pavel (Peer reviewed; Journal article, 2022)
      Copper oxide nanoparticles (CuO NPs) are increasingly used in various industry sectors. Moreover, medical application of CuO NPs as antimicrobials also contributes to human exposure. Their toxicity, including toxicity to ...

    • A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health 

      Mhaouty-Kodja, Sakina; Zalko, Daniel; Tait, Sabrina; Testai, Emanuela; Viguié, Catherine; Corsini, Emanuela; Buratti, Franca Maria; Cabaton, Nicolas J.; Coppola, Lucia; De la Vieja, Antonio; Dusinska, Maria; El Yamani, Naouale; Galbiati, Valentina; Iglesias-Hernández, Patricia; Kohl, Yvonne; Maddalon, Ambra; Marcon, Francesca; Naulé, Lydie; Rundén-Pran, Elise; Salani, Francesca; Santori, Nicoletta; Torres-Ruiz, Mónica; Turner, Jonathan D.; Adamovsky, Ondrej; Aiello-Holden, Kiara; Dirven, Hubert; Louro, Henriqueta; João Silva, Maria (Peer reviewed; Journal article, 2024)

    • Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report 

      Doak, Shareen H.; Andreoli, Cristina; Burgum, Michael J.; Chaudhry, Qasim; Bleeker, Eric; Bossa, Cecilia; Domenech, Josefa; Drobne, Damjana; Fessard, Valérie; Jeliazkova, Nina; Longhin, Eleonora Marta; Rundén-Pran, Elise; Stepnik, Maciej; El Yamani, Naouale; Catalán, Julia; Dusinska, Maria (Peer reviewed; Journal article, 2023)
      Genotoxicity testing for nanomaterials remains challenging as standard testing approaches require some adaptation, and further development of nano-specific OECD Test Guidelines (TGs) and Guidance Documents (GDs) are needed. ...

    • Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models 

      Buociková, Verona; Longhin, Eleonora Marta; Pilalis, Eleftherios; Mastrokalou, Chara; Miklíková, Svetlana; Cihova, Marina; Poturnayova, Alexandra; Mackova, Katarina; Bábelová, Andrea; Trnkova, Lenka; El Yamani, Naouale; Zheng, Congying; Rios-Mondragon, Ivan; Labudova, Martina; Csaderova, Lucia; Kuracinova, Kristina Mikus; Makovicky, Peter; Kučerová, Lucia; Matuskova, Miroslava; Cimpan, Mihaela-Roxana; Dusinska, Maria; Babal, Pavel; Chatziioannou, Aristotelis; Gábelová, Alena; Rundén-Pran, Elise; Smolkova, Bozena (Peer reviewed; Journal article, 2022)
      Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer ...

    • Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpression 

      Buociková, Verona; Tyciakova, Sylvia; Pilalis, Eleftherios; Mastrokalou, Chara; Urbanova, Maria; Matuskova, Miroslava; Demkova, Lucia; Medova, Veronika; Longhin, Eleonora Marta; Rundén-Pran, Elise; Dusinska, Maria; Rios Mondragon, Ivan; Cimpan, Mihaela-Roxana; Gábelová, Alena; Soltysova, Andrea; Smolkova, Bozena; Chatziioannou, Aristotelis (Peer reviewed; Journal article, 2022)
      Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising ...

    • Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials 

      Elje, Elisabeth; Mariussen, Espen; McFadden, Erin; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2023)
      For the next-generation risk assessment (NGRA) of chemicals and nanomaterials, new approach methodologies (NAMs) are needed for hazard assessment in compliance with the 3R’s to reduce, replace and refine animal experiments. ...

    • DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death 

      Bonassi, Stefano; Ceppi, Marcello; Møller, Peter; Azqueta, Amaya; Milic, Mirta; Neri, Monica; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine A. S.; Teixeira, João Paulo; Bruzzone, Marco; Da Silva, Juliana; Benedetti, Danieli; Cavallo, Delia; Ursini, Cinzia Lucia; Giovannelli, Lisa; Moretti, Silvia; Riso, Patrizia; Del Bo, Cristian; Russo, Patrizia; Dobrzynska, Malgorzata; Goroshinskaya, Irina A.; Surikova, Ekaterina I.; Staruchova, Marta; Barancokova, Magdalena; Volkovova, Katarina; Kažimirova, Alena; Smolkova, Bozena; Laffon, Blanca; Valdiglesias, Vanessa; Pastor, Susana; Marcos, Ricard; Hernández, Alba; Gajski, Goran; Spremo-Potparević, Biljana; Zivkovic, Lada; Boutet-Robinet, Elisa; Perdry, Hervé; Lebailly, Pierre; Perez, Carlos L.; Basaran, Nursen; Nemeth, Zsuzsanna; Safar, Anna; Dusinska, Maria; Collins, Andrew Richard (Peer reviewed; Journal article, 2021)
      The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by ...

    • DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations 

      Niazi, Yasmeen; Thomsen, Hauke; Smolkova, Bozena; Vodickova, Ludmila; Vodenkova, Sona; Kroupa, Michal; Vymetalkova, Veronika; Kazimirova, Alena; Barancokova, Magdalena; Volkovova, Katarina; Staruchova, Marta; Hoffmann, Per; Nöthen, Markus; Dusinska, Maria; Musak, Ludovit; Vodicka, Pavel; Hemminki, Kari; Försti, Asta (Peer reviewed; Journal article, 2021)
      DNA damage and unrepaired or insufficiently repaired DNA double-strand breaks as well as telomere shortening contribute to the formation of structural chromosomal aberrations (CAs). Non-specific CAs have been used in the ...

    • Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms? 

      Gupta, Suchi Smita; Singh, Krishna P.; Gupta, Shailendra; Dusinska, Maria; Rahman, Qamar (Peer reviewed; Journal article, 2022)
      During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 ...