Blar i NILU på forfatter "El Yamani, Naouale"
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The alamar blue assay in the context of safety testing of nanomaterials
Longhin, Eleonora Marta; El Yamani, Naouale; Rundén-Pran, Elise; Dusinska, Maria (Peer reviewed; Journal article, 2022)The Alamar Blue (AB) assay is widely used to investigate cytotoxicity, cell proliferation and cellular metabolic activity within different fields of toxicology. The use of the assay with nanomaterials (NMs) entails specific ... -
The colony forming efficiency assay for toxicity testing of nanomaterials – Modifications for higher-throughput
Rundén-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Elje, Elisabeth; Longhin, Eleonora Marta (Peer reviewed; Journal article, 2022)To cope with the high number of nanomaterials manufactured, it is essential to develop high-throughput methods for in vitro toxicity screening. At the same time, the issue with interference of the nanomaterial (NM) with ... -
Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report
Doak, Shareen H.; Andreoli, Cristina; Burgum, Michael J.; Chaudhry, Qasim; Bleeker, Eric; Bossa, Cecilia; Domenech, Josefa; Drobne, Damjana; Fessard, Valérie; Jeliazkova, Nina; Longhin, Eleonora Marta; Rundén-Pran, Elise; Stepnik, Maciej; El Yamani, Naouale; Catalán, Julia; Dusinska, Maria (Peer reviewed; Journal article, 2023)Genotoxicity testing for nanomaterials remains challenging as standard testing approaches require some adaptation, and further development of nano-specific OECD Test Guidelines (TGs) and Guidance Documents (GDs) are needed. ... -
Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models
Buociková, Verona; Longhin, Eleonora Marta; Pilalis, Eleftherios; Mastrokalou, Chara; Miklíková, Svetlana; Cihova, Marina; Poturnayova, Alexandra; Mackova, Katarina; Bábelová, Andrea; Trnkova, Lenka; El Yamani, Naouale; Zheng, Congying; Rios-Mondragon, Ivan; Labudova, Martina; Csaderova, Lucia; Kuracinova, Kristina Mikus; Makovicky, Peter; Kučerová, Lucia; Matuskova, Miroslava; Cimpan, Mihaela-Roxana; Dusinska, Maria; Babal, Pavel; Chatziioannou, Aristotelis; Gábelová, Alena; Rundén-Pran, Elise; Smolkova, Bozena (Peer reviewed; Journal article, 2022)Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer ... -
DNA damage in blood cells in relation to chemotherapy and nutritional status in colorectal cancer patients — A pilot study
Kværner, Ane Sørlie; Minaguchi, Jun; El Yamani, Naouale; Henriksen, Christine; Ræder, Hanna; Paur, Ingvild; Henriksen, Hege; Wiedswang, Gro; Smeland, Sigbjørn; Blomhoff, Rune; Collins, Andrew Richard; Bøhn, Siv Kjølsrud (Journal article; Peer reviewed, 2018) -
Effects of Titanium Dioxide Nanoparticles on the Hprt Gene Mutations in V79 Hamster Cells
Kazimirova, Alena; El Yamani, Naouale; Rubio, Laura; Garcia-Rodriguez, Alba; Barancokova, Magdalena; Marcos, Ricard; Dusinska, Maria (Peer reviewed; Journal article, 2020)The genotoxicity of anatase/rutile TiO2 nanoparticles (TiO2 NPs, NM105 at 3, 15 and 75 µg/cm2) was assessed with the mammalian in-vitro Hypoxanthine guanine phosphoribosyl transferase (Hprt) gene mutation test in Chinese ... -
Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives
Buociková, Verona; Rios-Mondragon, Ivan; Pilalis, Eleftherios; Chatziioannou, Aristotelis; Miklíková, Svetlana; Mego, Michal; Pajuste, Karlis; Rucins, Martins; El Yamani, Naouale; Longhin, Eleonora Marte; Sobolev, Arkadij; Freixanet, Muriel; Puntes, Victor; Plotniece, Aiva; Dusinska, Maria; Cimpan, Mihaela Roxana; Gábelová, Alena; Smolková, Božena (Peer reviewed; Journal article, 2020)Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. ... -
Epigenetics in breast cancer therapy—New strategies and future nanomedicine perspectives
Buociková, Verona; Rios Mondragon, Ivan; Pilalis, Eleftherios; Chatziioannou, Aristotelis; Miklíková, Svetlana; Mego, Michal; Pajuste, Karlis; Rucins, Martins; El Yamani, Naouale; Longhin, Eleonora Marte; Sobolev, Arkadij; Freixanet, Muriel; Puntes, Victor; Plotniece, Aiva; Dusinska, Maria; Cimpan, Mihaela Roxana; Gábelová, Alena; Smolková, Božena (Peer reviewed; Journal article, 2020)Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. ... -
Genotoxic effects of occupational exposure to glass fibres - A human biomonitoring study
Ceppi, Marcello; Smolkova, Bozena; Staruchova, Marta; Kazimirova, Alena; Barancokova, Magdalena; Volkovova, Katarina; Collins, Andrew Richard; Kocan, Anton; Dzupinkova, Zuzana; Horska, Alexandra; Buocikova, Verona; Tulinska, Jana; Liskova, Aurelia; Mikusova, Miroslava Lehotska; Wsolova, Ladislava; Kuba, Daniel; Rundén-Pran, Elise; El Yamani, Naouale; Longhin, Eleonora Marta; Halasova, Erika; Kyrtopoulos, Soterios; Bonassi, Stefano; Dusinska, Maria (Peer reviewed; Journal article, 2023)As part of a large human biomonitoring study, we conducted occupational monitoring in a glass fibre factory in Slovakia. Shopfloor workers (n = 80), with a matched group of administrators in the same factory (n = 36), were ... -
Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment - A Review
Kohl, Yvonne; Rundén-Pran, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora Marte; Dusinska, Maria (Peer reviewed; Journal article, 2020)Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal ... -
Global and gene specific DNA methylation in breast cancer cells was not affected during epithelial-to-mesenchymal transition in vitro
Smolkova, B.; Miklikova, S.; Kajabova, V. H.; Babelova, A.; El Yamani, Naouale; Zduriencikova, M.; Fridrichova, I.; Zmetakova, I.; Krivulcik, T.; Kalinkova, L.; Matuskova, M.; Kucerova, M.; Dusinska, Maria (Journal article; Peer reviewed, 2016) -
Hazard assessment of nanomaterials using in vitro toxicity assays: Guidance on potential assay interferences and mitigating actions to avoid biased results
El Yamani, Naouale; Rundén-Pran, Elise; Varet, Julia; Beus, Maja; Dusinska, Maria; Fessard, Valerie; Moschini, Elisa; Serchi, Tommaso; Cimpan, Mihaela-Roxana; Lynch, Iseult; Vinković Vrček, ivana (Peer reviewed; Journal article, 2024)The movement towards an animal-free testing approach for risk assessment represents a key paradigm shift in toxicology. Risk assessment of engineered and anthropogenic nanoscale materials (NM) is dependent on reliable ... -
Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity
El Yamani, Naouale; Mariussen, Espen; Gromelski, Maciej; Wyrzykowska, Ewelina; Grabarek, Dawid; Puzyn, Tomasz; Tanasescu, Speranta; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2022)Hazard identification and safety assessment of the huge variety of nanomaterials (NMs), calls for robust and validated toxicity screening tests in combination with cheminformatics approaches to identify factors that can ... -
High throughput toxicity screening and intracellular detection of nanomaterials
Collins, Andrew Richard; Balasubramanyam, Annangi; Rubio, Laura; Marcos, Ricard; Dorn, Marco; Merker, Carolin; Estrela-Lopis, Irina; Cimpan, Mihaela Roxana; Ibrahim, Mohamed; Cimpan, Emil; Ostermann, Melanie; Sauter, Alexander; El Yamani, Naouale; Shaposhnikov, Sergey; Chevillard, Sylvie; Paget, Vincent; Grall, Romain; Delic, Jozo; Goñi- de-Cerio, Felipe; Suarez-Merino, Blanca; Fessard, Valérie; Hogeveen, Kevin N; Fjellsbø, Lise Marie; Rundén-Pran, Elise; Brzicova, Tana; Topinka, Jan; João Silva, Maria; Leite, PE; Ribeiro, AR; Granjeiro, JM; Grafström, Roland; Prina-Mello, Adriele; Dusinska, Maria (Journal article; Peer reviewed, 2017) -
Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?
Dusinska, Maria; Tulinska, Jana; El Yamani, Naouale; Kuricova, Miroslava; Liskova, Aurelia; Rollerova, Eva; Rundén-Pran, Elise; Smolkova, Bozena (Journal article; Peer reviewed, 2017) -
Impact of nanosilver on various DNA lesions and HPRT gene mutations – effects of charge and surface coating
Huk, Anna; Izak-Nau, Emilia; El Yamani, Naouale; Uggerud, Hilde Thelle; Vadset, Marit; Zasonska, Beata; Duschl, Albert; Dusinska, Maria (Journal article; Peer reviewed, 2015) -
In vitro evaluation of the genotoxicity of poly(anhydride) nanoparticles designed for oral drug delivery
Iglesias, T.; Dusinska, Maria; El Yamani, Naouale; Irache, J. M.; Azqueta, A.; de Cerain, A. López (Journal article; Peer reviewed, 2017) -
In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment
El Yamani, Naouale; Collins, Andrew Richard; Rundén-Pran, Elise; Fjellsbø, Lise Marie; Shaposhnikov, Sergey; Zienolddiny, Shanbeh; Dusinska, Maria (Journal article; Peer reviewed, 2016) -
Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake
El Yamani, Naouale; Rubio, Laura; García-Rodríguez, Alba; Kažimírová, Alena; Rundén-Pran, Elise; Barančoková, Magdaléna; Marcos, Ricard; Dusinska, Maria (Peer reviewed; Journal article, 2022)The potential genotoxicity of titanium dioxide (TiO2) nanoparticles (NPs) is a conflictive topic because both positive and negative findings have been reported. To add clarity, we have carried out a study with two cell ... -
The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials
El Yamani, Naouale; Rundén-Pran, Elise; Collins, Andrew Richard; Longhin, Eleonora Marta; Elje, Elisabeth; Hoet, Peter; Vrček, Ivana Vinković; Doak, Shareen H.; Fessard, Valérie; Dusinska, Maria (Peer reviewed; Journal article, 2022)The in vitro comet assay is a widely applied method for investigating genotoxicity of chemicals including engineered nanomaterials (NMs). A big challenge in hazard assessment of NMs is possible interference between the NMs ...