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dc.contributor.authorHansen, Elisabeth
dc.contributor.authorHuber, Nikolaus
dc.contributor.authorBustnes, Jan O.
dc.contributor.authorHerzke, Dorte
dc.contributor.authorBårdsen, Bård-Jørgen
dc.contributor.authorEulaers, Igor
dc.contributor.authorJohnsen, Trond V.
dc.contributor.authorBourgeon, Sophie
dc.date.accessioned2020-06-25T08:38:33Z
dc.date.available2020-06-25T08:38:33Z
dc.date.issued2020
dc.identifier.citationEnvironment International. 2020, 142, 105861.en_US
dc.identifier.issn0160-4120
dc.identifier.urihttps://hdl.handle.net/11250/2659443
dc.description.abstractApex predators are characterized by high levels of biomagnifying organohalogenated contaminants (OHCs) which have been found to induce detrimental health effects in wildlife, such as immune system impairment. The leukocyte coping capacity (LCC) assay is a functional real-time measure of an innate immune response essential in pathogen resistance, known as the respiratory burst. The current study suggests the novel use of this tool to test whether OHCs impair the innate immune system of a sentinel top predator, the white-tailed eagle (Haliaeetus albicilla; WTE). The LCC analysis was performed in the field on WTE nestlings (n = 84) from northern Norway over two breeding seasons. Poly- and perfluoroalkyl substances (PFAS) dominated the total OHC load, surpassing the levels of legacy organochlorines. In addition, we detected significant negative correlations between concentrations of all polychlorinated biphenyls, p,p′-dichlorodiphenyldichloroethylene, perfluorohexane sulfonic acid and long-chain perfluorocarboxylic acids and the LCC of WTE nestlings. Based on our current findings reflecting a potential negative effect of both emerging and legacy OHCs on innate immune capacity, we suggest LCC to be a relevant and accessible test expanding the ecotoxicological toolbox to assess sub-lethal effects of OHCs in apex avian wildlife.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleA novel use of the leukocyte coping capacity assay to assess the immunomodulatory effects of organohalogenated contaminants in avian wildlifeen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2020 The Author(s). Published by Elsevier Ltd.en_US
dc.source.pagenumber105861en_US
dc.source.volume142en_US
dc.source.journalEnvironment Internationalen_US
dc.identifier.doi10.1016/j.envint.2020.105861
dc.identifier.cristin1817528
dc.identifier.cristin1817528
dc.relation.projectNorges forskningsråd: 255681en_US
dc.relation.projectNILU: 116098en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal