Blar i Vitenskapelige publikasjoner på tidsskrift "Nanomaterials"
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Advanced Respiratory Models for Hazard Assessment of Nanomaterials. Performance of Mono-, Co- and Tricultures
(Peer reviewed; Journal article, 2022)Advanced in vitro models are needed to support next-generation risk assessment (NGRA), moving from hazard assessment based mainly on animal studies to the application of new alternative methods (NAMs). Advanced models must ... -
Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials
(Peer reviewed; Journal article, 2023)For the next-generation risk assessment (NGRA) of chemicals and nanomaterials, new approach methodologies (NAMs) are needed for hazard assessment in compliance with the 3R’s to reduce, replace and refine animal experiments. ... -
Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
(Peer reviewed; Journal article, 2022)During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 ... -
Effects of Titanium Dioxide Nanoparticles on the Hprt Gene Mutations in V79 Hamster Cells
(Peer reviewed; Journal article, 2020)The genotoxicity of anatase/rutile TiO2 nanoparticles (TiO2 NPs, NM105 at 3, 15 and 75 µg/cm2) was assessed with the mammalian in-vitro Hypoxanthine guanine phosphoribosyl transferase (Hprt) gene mutation test in Chinese ... -
Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment - A Review
(Peer reviewed; Journal article, 2020)Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal ... -
Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model
(Peer reviewed; Journal article, 2020)(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures ... -
Improving Quality in Nanoparticle-Induced Cytotoxicity Testing by a Tiered Inter-Laboratory Comparison Study
(Peer reviewed; Journal article, 2020)The quality and relevance of nanosafety studies constitute major challenges to ensure their key role as a supporting tool in sustainable innovation, and subsequent competitive economic advantage. However, the number of ... -
An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform
(Peer reviewed; Journal article, 2022)A freely available “in vitro dosimetry” web application is presented enabling users to predict the concentration of nanomaterials reaching the cell surface, and therefore available for attachment and internalization, from ... -
Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation
(Peer reviewed; Journal article, 2022)Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies ... -
Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation
(Peer reviewed; Journal article, 2023)Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects ...