dc.contributor.author | Rostkowski, Pawel Marian | |
dc.contributor.author | Haglund, Peter | |
dc.contributor.author | Aalizadeh, Reza | |
dc.contributor.author | Alygizakis, Nikiforos | |
dc.contributor.author | Thomaidis, Nikolaos | |
dc.contributor.author | Arandes, J. | |
dc.contributor.author | Bohlin-Nizzetto, Pernilla | |
dc.contributor.author | Booij, P. | |
dc.contributor.author | Budzinski, Hélène | |
dc.contributor.author | Brunswick, Pamela | |
dc.contributor.author | Covaci, Adrian | |
dc.contributor.author | Gallampois, Christine | |
dc.contributor.author | Grosse, Sylvia | |
dc.contributor.author | Hindle, R. | |
dc.contributor.author | Ipolyi, Ildiko | |
dc.contributor.author | Jobst, Karl | |
dc.contributor.author | Kaserzon, Sarit | |
dc.contributor.author | Leonards, Pim | |
dc.contributor.author | Lestremau, F. | |
dc.contributor.author | Letzel, Thomas | |
dc.contributor.author | Magnér, Jörgen | |
dc.contributor.author | Matsukami, Hidenori | |
dc.contributor.author | Moschet, C. | |
dc.contributor.author | Oswald, Peter | |
dc.contributor.author | Plassmann, M. | |
dc.contributor.author | Slobodnik, Jaroslav | |
dc.contributor.author | Yang, Chun | |
dc.date.accessioned | 2019-05-08T07:34:39Z | |
dc.date.available | 2019-05-08T07:34:39Z | |
dc.date.created | 2019-03-05T15:52:41Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Analytical and Bioanalytical Chemistry. 2019, 411 1957-1977. | nb_NO |
dc.identifier.issn | 1618-2642 | |
dc.identifier.uri | http://hdl.handle.net/11250/2596904 | |
dc.description.abstract | Untargeted analysis of a composite house dust sample has been performed as part of a collaborative effort to evaluate the progress in the field of suspect and nontarget screening and build an extensive database of organic indoor environment contaminants. Twenty-one participants reported results that were curated by the organizers of the collaborative trial. In total, nearly 2350 compounds were identified (18%) or tentatively identified (25% at confidence level 2 and 58% at confidence level 3), making the collaborative trial a success. However, a relatively small share (37%) of all compounds were reported by more than one participant, which shows that there is plenty of room for improvement in the field of suspect and nontarget screening. An even a smaller share (5%) of the total number of compounds were detected using both liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS). Thus, the two MS techniques are highly complementary. Most of the compounds were detected using LC with electrospray ionization (ESI) MS and comprehensive 2D GC (GC×GC) with atmospheric pressure chemical ionization (APCI) and electron ionization (EI), respectively. Collectively, the three techniques accounted for more than 75% of the reported compounds. Glycols, pharmaceuticals, pesticides, and various biogenic compounds dominated among the compounds reported by LC-MS participants, while hydrocarbons, hydrocarbon derivatives, and chlorinated paraffins and chlorinated biphenyls were primarily reported by GC-MS participants. Plastics additives, flavor and fragrances, and personal care products were reported by both LC-MS and GC-MS participants. It was concluded that the use of multiple analytical techniques was required for a comprehensive characterization of house dust contaminants. Further, several recommendations are given for improved suspect and nontarget screening of house dust and other indoor environment samples, including the use of open-source data processing tools. One of the tools allowed provisional identification of almost 500 compounds that had not been reported by participants. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The strength in numbers: comprehensive characterization of house dust using complementary mass spectrometric techniques | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | © The Author(s) 2019 | nb_NO |
dc.source.pagenumber | 1957-1977 | nb_NO |
dc.source.volume | 411 | nb_NO |
dc.source.journal | Analytical and Bioanalytical Chemistry | nb_NO |
dc.identifier.doi | 10.1007/s00216-019-01615-6 | |
dc.identifier.cristin | 1682465 | |
dc.relation.project | NILU - Norsk institutt for luftforskning: 115019 | nb_NO |
cristin.unitcode | 7460,60,0,0 | |
cristin.unitname | Miljøkjemi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |