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dc.contributor.authorNeerland, Eirik D.
dc.contributor.authorBytingsvik, Jenny
dc.contributor.authorNikiforov, Vladimir
dc.contributor.authorEvenset, Anita
dc.contributor.authorKrøkje, Åse
dc.date.accessioned2020-01-28T08:52:54Z
dc.date.available2020-01-28T08:52:54Z
dc.date.created2019-10-10T12:59:31Z
dc.date.issued2019
dc.identifier.citationEnvironmental Toxicology and Chemistry. 2019, 38 (11), 2405-2413.nb_NO
dc.identifier.issn0730-7268
dc.identifier.urihttp://hdl.handle.net/11250/2638208
dc.description.abstractHigh levels of organochlorine contaminants (OCs) have been found in arctic char (Salvelinus alpinus) from Lake Ellasjøen, Bjørnøya (Norwegian Arctic). The aim of the present study was to investigate the potential genotoxic effect of environmental organochlorine contaminant exposure in arctic char from Ellasjøen compared with arctic char from the low‐contaminated Lake Laksvatn nearby. Blood was analyzed using agarose gel electrophoresis and image data analysis to quantify the fraction of total DNA that migrated into the gel (DNA‐FTM) as a relative measure of DNA double‐strand breaks (DSBs). Analysis by GC‐MS of muscle samples showed an average 43 times higher concentration of ΣOCs in arctic char from Ellasjøen (n = 18) compared with Laksvatn char (n = 21). Char from Lake Ellasjøen had a much higher frequency of DSBs, as measured by DNA‐FTM, than char from Lake Laksvatn. Principal component analysis and multiple linear regressions show that there was a significant positive relationship between DSBs and levels of organochlorine contaminants in the char. In addition, DSBs were less frequent in reproductively mature char than in immature char. The results suggest that organochlorine contaminants are genotoxic to arctic char.nb_NO
dc.description.abstractDNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arcticnb_NO
dc.language.isoengnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleDNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arcticnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© 2019 The Authorsnb_NO
dc.source.pagenumber2405-2413nb_NO
dc.source.volume38nb_NO
dc.source.journalEnvironmental Toxicology and Chemistrynb_NO
dc.source.issue11nb_NO
dc.identifier.doi10.1002/etc.4546
dc.identifier.cristin1735983
dc.relation.projectNorges forskningsråd: 221371nb_NO
dc.relation.projectFramsenteret: Flagship "Hazardous substances"nb_NO
cristin.unitcode7460,60,0,0
cristin.unitnameMiljøkjemi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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