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dc.contributor.authorKohl, Yvonne
dc.contributor.authorRundén-Pran, Elise
dc.contributor.authorMariussen, Espen
dc.contributor.authorHesler, Michelle
dc.contributor.authorEl Yamani, Naouale
dc.contributor.authorLonghin, Eleonora Marte
dc.contributor.authorDusinska, Maria
dc.date.accessioned2020-10-08T09:28:09Z
dc.date.available2020-10-08T09:28:09Z
dc.date.created2020-10-05T13:56:18Z
dc.date.issued2020
dc.identifier.citationNanomaterials. 2020, 10, E1911.en_US
dc.identifier.issn2079-4991
dc.identifier.urihttps://hdl.handle.net/11250/2681708
dc.description.abstractChanges in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal or (during mitosis) whole genome level. The study of mechanisms leading to genotoxicity is crucially important, as well as the detection of potentially genotoxic compounds. We consider the current state of the art and describe here the main endpoints applied in standard human in vitro models as well as new advanced 3D models that are closer to the in vivo situation. We performed a literature review of in vitro studies published from 2000–2020 (August) dedicated to the genotoxicity of nanomaterials (NMs) in new models. Methods suitable for detection of genotoxicity of NMs will be presented with a focus on advances in miniaturization, organ-on-a-chip and high throughput methods.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment - A Reviewen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.source.volume10en_US
dc.source.journalNanomaterialsen_US
dc.identifier.doi10.3390/nano10101911
dc.identifier.cristin1837108
dc.relation.projectEC/H2020/857381en_US
dc.relation.projectNorges forskningsråd: 310571en_US
dc.relation.projectEC/H2020/814425en_US
dc.relation.projectEC/H2020/814572en_US
dc.relation.projectNorges forskningsråd: 310565en_US
dc.relation.projectNorges forskningsråd: 288768en_US
dc.relation.projectNorges forskningsråd: 271075en_US
dc.relation.projectEC/H2020/862296en_US
dc.relation.projectNILU: 119149en_US
dc.relation.projectNILU: 119011en_US
dc.relation.projectNILU: 119012en_US
dc.relation.projectNILU: 120065en_US
dc.relation.projectNILU: 117048en_US
dc.relation.projectNILU: 119044en_US
dc.relation.projectNILU: 119125en_US
dc.relation.projectNILU: 120080en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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