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dc.contributor.authorKohl, Yvonne
dc.contributor.authorBiehl, Margit
dc.contributor.authorSpring, Sarah
dc.contributor.authorHesler, Michelle
dc.contributor.authorOgourtsov, Vladimir
dc.contributor.authorTodorovic, Miomir
dc.contributor.authorOwen, Joshua
dc.contributor.authorElje, Elisabeth
dc.contributor.authorKopecka, Kristina
dc.contributor.authorMoriones, Oscar Hernando
dc.contributor.authorBastus, Neus G.
dc.contributor.authorSimon, Peter
dc.contributor.authorDubaj, Tibor
dc.contributor.authorRundén-Pran, Elise
dc.contributor.authorPuntes, Victor
dc.contributor.authorWilliam, Nicola
dc.contributor.authorvon Briesen, Hagen
dc.contributor.authorWagner, Sylvia
dc.contributor.authorKapur, Nikil
dc.contributor.authorMariussen, Espen
dc.contributor.authorNelson, Andrew
dc.contributor.authorGabelova, A
dc.contributor.authorDusinska, Maria
dc.contributor.authorVelten, Thomas
dc.contributor.authorKnoll, Thorsten
dc.date.accessioned2021-01-27T08:58:21Z
dc.date.available2021-01-27T08:58:21Z
dc.date.created2021-01-22T14:35:41Z
dc.date.issued2021
dc.identifier.citationSmall. 2021, 2006012.en_US
dc.identifier.issn1613-6810
dc.identifier.urihttps://hdl.handle.net/11250/2724914
dc.description.abstractMicrofluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal‐free risk assessment of new chemicals and drugs. Microfluidic cell‐based devices allow high‐throughput screening and flexible automation while lowering costs and reagent consumption due to their miniaturization. There is a growing need for faster and animal‐free approaches for drug development and safety assessment of chemicals (Registration, Evaluation, Authorisation and Restriction of Chemical Substances, REACH). The work presented describes a microfluidic platform for in vivo‐like in vitro cell cultivation. It is equipped with a wafer‐based silicon chip including integrated electrodes and a microcavity. A proof‐of‐concept using different relevant cell models shows its suitability for label‐free assessment of cytotoxic effects. A miniaturized microscope within each module monitors cell morphology and proliferation. Electrodes integrated in the microfluidic channels allow the noninvasive monitoring of barrier integrity followed by a label‐free assessment of cytotoxic effects. Each microfluidic cell cultivation module can be operated individually or be interconnected in a flexible way. The interconnection of the different modules aims at simulation of the whole‐body exposure and response and can contribute to the replacement of animal testing in risk assessment studies in compliance with the 3Rs to replace, reduce, and refine animal experiments.en_US
dc.language.isoengen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleMicrofluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screeningen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 The Authors.en_US
dc.source.journalSmallen_US
dc.identifier.doi10.1002/smll.202006012
dc.identifier.cristin1877269
dc.relation.projectEC/H2020/857381en_US
dc.relation.projectEC/H2020/685817en_US
dc.relation.projectNorges forskningsråd: 271075en_US
dc.relation.projectNorges forskningsråd: 246672en_US
dc.relation.projectNorges forskningsråd: 272412en_US
dc.relation.projectNILU: 117062
dc.relation.projectNILU: 117048
dc.relation.projectNILU: 119125
dc.relation.projectNILU: 116073
dc.source.articlenumber2006012en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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