dc.contributor.author | Mikusova, Miroslava Lehotska | |
dc.contributor.author | Busova, Milena | |
dc.contributor.author | Tulinska, Jana | |
dc.contributor.author | Masanova, Vlasta | |
dc.contributor.author | Liskova, Aurelia | |
dc.contributor.author | Uhnakova, Iveta | |
dc.contributor.author | Dusinska, Maria | |
dc.contributor.author | Krivosikova, Zora | |
dc.contributor.author | Rollerova, Eva | |
dc.contributor.author | Alacova, Radka | |
dc.contributor.author | Wsolova, Ladislava | |
dc.contributor.author | Horvathova, Mira | |
dc.contributor.author | Szabova, Michaela | |
dc.contributor.author | Lukan, Norbert | |
dc.contributor.author | Vecera, Zbynek | |
dc.contributor.author | Coufalik, Pavel | |
dc.contributor.author | Krumal, Kamil | |
dc.contributor.author | Alexa, Lukas | |
dc.contributor.author | Thon, Vojtech | |
dc.contributor.author | Piler, Pavel | |
dc.contributor.author | Buchtova, Marcela | |
dc.contributor.author | Vrlikova, Lucie | |
dc.contributor.author | Moravec, Pavel | |
dc.contributor.author | Mikuska, Pavel | |
dc.date.accessioned | 2023-03-01T12:12:28Z | |
dc.date.available | 2023-03-01T12:12:28Z | |
dc.date.created | 2023-02-28T12:56:47Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nanomaterials. 2023, 13, 767. | en_US |
dc.identifier.issn | 2079-4991 | |
dc.identifier.uri | https://hdl.handle.net/11250/3054970 | |
dc.description.abstract | Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects of TiO2 NPs using a whole-body inhalation chamber model are rare. In this study, the profile of lymphocyte markers, functional immunoassays, and antioxidant defense markers were analyzed to evaluate the potential adverse effects of seven-week inhalation exposure to two different concentrations of TiO2 NPs (0.00167 and 0.1308 mg TiO2/m3) in mice. A dose-dependent effect of TiO2 NPs on innate immunity was evident in the form of stimulated phagocytic activity of monocytes in low-dose mice and suppressed secretory function of monocytes (IL-18) in high-dose animals. The effect of TiO2 NPs on adaptive immunity, manifested in the spleen by a decrease in the percentage of T-cells, a reduction in T-helper cells, and a dose-dependent decrease in lymphocyte cytokine production, may indicate immunosuppression in exposed mice. The dose-dependent increase in GSH concentration and GSH/GSSG ratio in whole blood demonstrated stimulated antioxidant defense against oxidative stress induced by TiO2 NP exposure. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation | en_US |
dc.title.alternative | Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. | en_US |
dc.source.volume | 13 | en_US |
dc.source.journal | Nanomaterials | en_US |
dc.identifier.doi | 10.3390/nano13040767 | |
dc.identifier.cristin | 2130086 | |
dc.relation.project | EC/H2020/857560 | en_US |
dc.relation.project | EC/FP7/214547-2 | en_US |
dc.source.articlenumber | 767 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |