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dc.contributor.authorCioni, Lara
dc.contributor.authorNikiforov, Vladimir
dc.contributor.authorBenskin, Jonathan P.
dc.contributor.authorCoelho, Ana Carolina
dc.contributor.authorDudášová, Silvia
dc.contributor.authorLauria, Melanie
dc.contributor.authorLechtenfeld, Oliver J.
dc.contributor.authorPlassmann, Merle M.
dc.contributor.authorReemtsma, Thorsten
dc.contributor.authorSandanger, Torkjel Manning
dc.contributor.authorHerzke, Dorte
dc.date.accessioned2024-08-27T10:37:26Z
dc.date.available2024-08-27T10:37:26Z
dc.date.created2024-08-26T12:51:10Z
dc.date.issued2024
dc.identifier.citationEnvironmental Science and Technology. 2024, 58, 12943-12953.en_US
dc.identifier.issn0013-936X
dc.identifier.urihttps://hdl.handle.net/11250/3148632
dc.description.abstractA growing number of studies have reported that routinely monitored per- and polyfluoroalkyl substances (PFAS) are not sufficient to explain the extractable organic fluorine (EOF) measured in human blood. In this study, we address this gap by screening pooled human serum collected over 3 decades (1986–2015) in Tromsø (Norway) for >5000 PFAS and >300 fluorinated pharmaceuticals. We combined multiple analytical techniques (direct infusion Fourier transform ion cyclotron resonance mass spectrometry, liquid chromatography-Orbitrap-high-resolution mass spectrometry, and total oxidizable precursors assay) in a three-step suspect screening process which aimed at unequivocal suspect identification. This approach uncovered the presence of one PFAS and eight fluorinated pharmaceuticals (including some metabolites) in human serum. While the PFAS suspect only accounted for 2–4% of the EOF, fluorinated pharmaceuticals accounted for 0–63% of the EOF, and their contribution increased in recent years. Although fluorinated pharmaceuticals often contain only 1–3 fluorine atoms, our results indicate that they can contribute significantly to the EOF. Indeed, the contribution from fluorinated pharmaceuticals allowed us to close the organofluorine mass balance in pooled serum from 2015, indicating a good understanding of organofluorine compounds in humans. However, a portion of the EOF in human serum from 1986 and 2007 still remained unexplained.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCombining Advanced Analytical Methodologies to Uncover Suspect PFAS and Fluorinated Pharmaceutical Contributions to Extractable Organic Fluorine in Human Serum (Tromsø Study)en_US
dc.title.alternativeCombining Advanced Analytical Methodologies to Uncover Suspect PFAS and Fluorinated Pharmaceutical Contributions to Extractable Organic Fluorine in Human Serum (Tromsø Study)en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2024 The Authors. Published by American Chemical Society.en_US
dc.source.pagenumber12943-12953en_US
dc.source.volume58en_US
dc.source.journalEnvironmental Science and Technologyen_US
dc.identifier.doi10.1021/acs.est.4c03758
dc.identifier.cristin2289413
dc.relation.projectEC/H2020/860665en_US
dc.relation.projectNILU: 120021
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal